Regulation of Endothelial Progenitor Cells by Short-Term Exercise

Aging Clinical Trial

— EPC-Ex  

Official title:

Regulation of Endothelial Progenitor Cells by Short-Term Exercise

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT01169831
• Other study ID #: HP-00045413
• Status: Active, not recruiting
• Phase: N/A
• Start date: July 2011
• Est. completion date: December 31, 2023

Study information

• Verified date: April 2023
• Source: Baltimore VA Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 60
• Est. completion date: December 31, 2023
• Est. primary completion date: November 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

Exclusion Criteria:

• history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension

Related Conditions & MeSH terms

• Aging
• Cardiovascular Disease
• Cardiovascular Diseases
• Exercise

Intervention

Other:
• Exercise Training
2 weeks of daily aerobic exercise training
• Exercise Cessation
Stopping all exercise for 2 weeks

Locations

Country	Name	City	State
United States	University of Maryland, Baltimore & Baltimore VA Medical Center	Baltimore	Maryland

Sponsors (3)

Lead Sponsor	Collaborator
Baltimore VA Medical Center	University of Maryland, Baltimore, University of Maryland, College Park

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Baseline Endothelial progenitor cell number		Day 1
Primary	Final Endothelial Progenitor Cell Number		Day 15
Secondary	Baseline Endothelial Reactivity		Day 1
Secondary	Final Endothelial Reactivity		Day 15

External Links

•   University of Maryland Claude D. Pepper Older Americans Independence Center