Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality

Aging Clinical Trial

— HK-ASAP  

Official title:

Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): an Observational Study on Brain Health and Sleep Quality in Community-dwelling Older Adults

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06170073
• Other study ID #: 2023.496
• Status: Recruiting
• Start date: October 1, 2023
• Est. completion date: March 31, 2025

Study information

• Verified date: December 2023
• Source: Chinese University of Hong Kong
• Contact: Hanna LU, PhD
• Phone: 28314305
• Email: hannalu[@]cuhk.edu.hk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Poor sleep quality can significantly jeopardize the brain health, cognitive functions, daily activities, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and therefore potentially model, the effects of sleep quality on cognition and brain health are of great pragmatic values.

Description:

Objectives: This study aims to investigate the cognitive changes in older adults with sleep disturbances, examine the neuroimaging contributors to poor sleep quality and cognitive deficits.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 244
• Est. completion date: March 31, 2025
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 55 Years to 95 Years

Eligibility

Inclusion Criteria:

• Chinese old adults are the ones who are over 60 years of chronological age.
• Sleep disturbance: individual's subjective sleep quality is assessed using the Pittsburgh Sleep Quality Index (PSQI) with a total score >5.

Exclusion Criteria:

• History of bipolar disorders or psychosis.
• History of major neurological de?cits, including stroke, transient ischemic attack or brain tumor.
• Unable to participant magnetic resonance imaging (MRI) scanning.

Related Conditions & MeSH terms

• Aging
• Brain Disease
• Brain Diseases
• Cognitive Decline
• Cognitive Dysfunction
• Dyssomnias
• Parasomnias
• Sleep Disturbance

Locations

Country	Name	City	State
Hong Kong	The Chinese University of Hong Kong	Hong Kong	Tai Po

Sponsors (2)

Lead Sponsor	Collaborator
Chinese University of Hong Kong	The University of Hong Kong

Country where clinical trial is conducted

Hong Kong, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Sleep quality will be measured by the Pittsburgh Sleep Quality Index (PSQI)	Pittsburgh Sleep Quality Index (PSQI) is a validated 19-item self-reported questionnaire	Baseline
Primary	Global cognition will be measured by the Montreal Cognitive Assessment Hong Kong version (HK MoCA)	The Montreal Cognitive Assessment Hong Kong version (HK MoCA) is a validated and widely used screening assessment for detecting cognitive impairment, which measures an array of cognitive functions such as visuospatial, memory, language and attention.	Baseline
Primary	Complex attention will be measured by the Attention Network Test (ANT)	The ANT paradigm, as a computerized test, was used and performed by E-Prime 3.0.	Baseline
Secondary	Memory and learning will be measured by the Word list learning test (WLLT)	Word list learning test (WLLT), consisting of fifteen semantically non-associated words that is presented consecutively over three free trials of immediate recall, a 20-min delayed recall and followed by yes/no recognition.	Baseline
Secondary	Executive functions will be measured by the category verbal fluency test (CVFT)	On each trial of CVFT, the participants will be asked to overtly generate words in the animal category, fruit category and vegetable category as many as possible within 60 seconds	Baseline
Secondary	The levels of Aß40 and Aß42 will be measured by saliva analysis	saliva samples will be collected at a consistent time of day to avoid circadian effects and will be kept on ice during the collection.	Baseline