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Clinical Trial Summary

BRAIN-M is a randomized controlled trial designed to examine the effects of a single bout or 12 weeks of blood-flow restriction training or high-intensity resistance training on cognitive function, brain health, muscular properties and physical performance in healthy older men 60-75 years old.


Clinical Trial Description

The BRAIN-M project is driven by the idea that understanding the mechanisms through which muscle and brain interact could offer new approaches to magnifying the beneficial and detrimental effects of exercise training on health at older age. Specifically, the investigators aim at identifying brain, blood, and muscle biomarkers that could serve as predictors of response to exercise training at either cognitive, brain, muscle or physical performance levels and study the associations between biomarkers in order to suggest a physiological model of brain-muscle and muscle-brain crosstalk in ageing. 60 male older adults (60-75y old) will be included in either 12 weeks of high-intense blood-flow restriction training (n = 20), muscle damaging resistance training (n = 20) or no exercise (n = 20). The control group will be asked to maintain their usual lifestyle. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05744167
Study type Interventional
Source Lithuanian Sports University
Contact Nerijus Masiulis, PhD
Phone +37037302621
Email nerijus.masiulis@lsu.lt
Status Recruiting
Phase N/A
Start date October 15, 2022
Completion date May 31, 2024

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