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NCT04064528 Clinical Trial

Effects of Age on Amino Acid Delivery to Tendon

Aging Clinical Trial

Official title:
Effects of Age on Amino Acid Delivery to Tendon

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04064528
Other study ID # 1904022075
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 6, 2019
Est. completion date August 1, 2023

Study information
Verified date December 2023
Source Purdue University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Dietary amino acid supplementation may provide an effective means to promote tendon injury recovery and enhance collagen synthesis. While most published research has been completed in animal models, research with young adults has shown that a leucine-rich whey isolate consumed during a chronic resistance training (RT) intervention resulted in greater gains (~60%) in tendon CSA when compared to placebo. Leucine-rich diets have also improved tendon collagen content in rodents. Further, in our preliminary work utilizing microdialysis, we demonstrate that oral consumption of a leucine-rich amino acid beverage increased delivery of amino acids to tendons in young adults (21-30 years). However, whether aging alters the delivery of amino acids to tendons after oral consumption has not be investigated. In order to optimize amino acid dosing for chronic interventional studies, we wish to determine if aging influences amino acid concentration in the peritendinous (space around the tendon) space after oral consumption.

Recruitment information / eligibility
Status Completed
Enrollment 20
Est. completion date August 1, 2023
Est. primary completion date August 1, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 21 Years to 75 Years
Eligibility Inclusion Criteria: - Exclusion Criteria: - body mass index >35 kg•m-2, those on medications known to affect protein or collagen metabolism, e.g. acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors, previous history of tendinopathy, or diabetes.

Study Design

Related Conditions & MeSH terms

Intervention

Dietary Supplement:
• Amino Acids
10 g bolus of essential amino acids

Locations
Country Name City State
United States Purdue University West Lafayette Indiana

Sponsors (1)
Lead Sponsor Collaborator
Purdue University

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Achilles Peritendinous Amino Acid Levels in young and older adults Concentrations of amino acids will be measured from around the Achilles tendon 0-6 hours post consumption
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