Aging Clinical Trial
Official title:
Cerebral Networks of Locomotor Learning and Retention in Older Adults
Older adults often experience substantial deficits in walking ability, especially for walking tasks that are more complex such as obstacle crossing. This is due in part to changes in the brain that make performance of physical and cognitive tasks more difficult. Rehabilitation can help to improve walking ability, but effective rehabilitation is time consuming and expensive. New approaches are needed to improve the efficiency of rehabilitation so that gains in walking ability are widely attainable. A promising strategy is to focus on enhancing motor learning, which is defined as improved ability to perform a motor task due to practice or experience. The investigators will investigate the use of non-invasive brain stimulation to increase motor learning and retention of the newly learned walking skills. The investigators will also use neuroimaging to assess brain characteristics that explain how motor learning works. The knowledge gained from this study is expected to contribute to better understanding of mechanistic targets and intervention approaches to improve rehabilitation of walking.
Status | Recruiting |
Enrollment | 60 |
Est. completion date | September 30, 2024 |
Est. primary completion date | September 30, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility | Inclusion Criteria: - age 65 years or older - preferred 10m walking speed < 1.1 m/s - self-report of "some difficulty with walking tasks, such as becoming tired when walking a quarter mile, or when climbing two flights of stairs, or when performing household chores." - Willingness to be randomized to either study group and to participate in all aspects of study assessment and intervention Exclusion Criteria: - Diagnosed neurological disorder or injury of the central nervous system, or observation of symptoms consistent with such a condition (Alzheimer's, Parkinson's, stroke, etc.) - Contraindications to non-invasive brain stimulation (e.g., metal in head, wound on scalp) - Contraindications to magnetic resonance imaging (e.g., metal in body, claustrophobia, etc). - Use of medications affecting the central nervous system - severe arthritis, such as awaiting joint replacement - severe obesity (body mass index > 35) - current cardiovascular, lung or renal disease; diabetes; terminal illness - myocardial infarction or major heart surgery in the previous year - cancer treatment in the past year, except for nonmelanoma skin cancers and cancers having an excellent prognosis (e.g., early stage breast or prostate cancer) - current diagnosis of schizophrenia, other psychotic disorders, or bipolar disorder - uncontrolled hypertension at rest (systolic > 180 mmHg and/or diastolic > 100 mmHg) - bone fracture or joint replacement in the previous six months - current participation in physical therapy for lower extremity function or cardiopulmonary rehabilitation - current enrollment in any clinical trial - difficulty communicating with study personnel, and/or non-English speaking - planning to relocate out of the area during the study period - clinical judgment of investigative team regarding safety or non-compliance |
Country | Name | City | State |
---|---|---|---|
United States | North Florida/South Georgia Veterans Health System, Gainesville, FL | Gainesville | Florida |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Walking speed change from baseline | Change in the fastest safe walking speed over a complex walking course | Measured at follow up visit (approximately three weeks after baseline) | |
Secondary | Prefrontal cortex gray matter volume change from baseline | Change in the volume of gray matter in the prefrontal cortex, as measured by MRI | Measured at follow up visit (approximately three weeks after baseline) | |
Secondary | Brain resting state network segregation | Change in resting state network segregation. | Measured at follow up visit (approximately three weeks after baseline) |
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