Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation

Aging Clinical Trial

Official title:

Fatigability and Physical Performance: Effects of Resistance Training Variables Manipulation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03619070
• Other study ID #: 85052218.0.0000.5154
• Status: Recruiting
• Phase: N/A
• Start date: May 20, 2018
• Est. completion date: November 15, 2018

Study information

• Verified date: August 2018
• Source: Universidade Federal do Triangulo Mineiro
• Contact: Fabio L Orsatti, PhD
• Phone: +55343700-6634
• Email: fabiorsatti[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluate whether resistance training variables modulate the fatigability (power-duration relationship) and physical performance in adults and older adults

Description:

The resistance training variables manipulation is utilized for maximize the results of resistance training. However it is unclear whether the resistance training variables manipulation modulates the fatigability (i.e. power-duration relationship) and whether this explains the improvement on physical performance (i.e. gait speed, sit-to-stand and timed up and go tests).

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: November 15, 2018
• Est. primary completion date: September 30, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 50 Years and older

Eligibility

Inclusion Criteria:

• Postmenopausal women (>12 months amenorrhea) with age above or equal 50 years old.

• No hormone therapy or phytoestrogens

Exclusion Criteria:

• No-drinker alcohol (no alcohol intake whatsoever in their diet);

• Non- smokers;

• Hypertensive with uncontrolled blood pressure values;

• Diabetic with uncontrolled glycemia;

• Presence of arthropathies;

• Presence of myopathies;

• Skeletal musculotendinous disorder.

Related Conditions & MeSH terms

• Aging

Intervention

Other:
• Resistance training, LL
In LL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and low load (i.e. 30% of one repetition maximum)
• Resistance training, HL
In HL, the postmenopausal women will be submitted to 12 weeks of Resistance training with moderate volume (i.e. three sets per exercise) and high load (i.e. 80% of one repetition maximum)
• Resistance training, HVHL
In HVHL, the postmenopausal women will be submitted to 12 weeks of Resistance training with high volume (i.e. six sets per exercise) and hig load (i.e. 80% of one maximum repetition)
• Control group, CG
The CG groups do not will performed the exercise.

Locations

Country	Name	City	State
Brazil	Post-degree program in physical education	Uberaba	MG - Minas Gerais

Sponsors (1)

Lead Sponsor	Collaborator
Universidade Federal do Triangulo Mineiro

Country where clinical trial is conducted

Brazil, 

References & Publications (24)

Aagaard P, Simonsen EB, Andersen JL, Magnusson P, Dyhre-Poulsen P. Increased rate of force development and neural drive of human skeletal muscle following resistance training. J Appl Physiol (1985). 2002 Oct;93(4):1318-26. — View Citation

American College of Sports Medicine. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009 Mar;41(3):687-708. doi: 10.1249/MSS.0b013e3181915670. Review. — View Citation

Asikainen TM, Kukkonen-Harjula K, Miilunpalo S. Exercise for health for early postmenopausal women: a systematic review of randomised controlled trials. Sports Med. 2004;34(11):753-78. Review. — View Citation

Benini R, Prado Nunes PR, Orsatti CL, Barcelos LC, Orsatti FL. Effects of acute total body resistance exercise on hormonal and cytokines changes in men and women. J Sports Med Phys Fitness. 2015 Apr;55(4):337-44. — View Citation

Burnley M. Estimation of critical torque using intermittent isometric maximal voluntary contractions of the quadriceps in humans. J Appl Physiol (1985). 2009 Mar;106(3):975-83. doi: 10.1152/japplphysiol.91474.2008. Epub 2009 Jan 15. — View Citation

Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, Leveille SG, Fried LP, Md JM. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc. 2002 Dec;50(12):1947-54. — View Citation

Fink J, Kikuchi N, Yoshida S, Terada K, Nakazato K. Impact of high versus low fixed loads and non-linear training loads on muscle hypertrophy, strength and force development. Springerplus. 2016 May 20;5(1):698. doi: 10.1186/s40064-016-2333-z. eCollection 2016. — View Citation

Gurjão AL, Gobbi LT, Carneiro NH, Gonçalves R, Ferreira de Moura R, Cyrino ES, Altimari LR, Gobbi S. Effect of strength training on rate of force development in older women. Res Q Exerc Sport. 2012 Jun;83(2):268-75. — View Citation

Klass M, Baudry S, Duchateau J. Voluntary activation during maximal contraction with advancing age: a brief review. Eur J Appl Physiol. 2007 Jul;100(5):543-51. Epub 2006 Jun 9. Review. — View Citation

Lera Orsatti F, Nahas EA, Maestá N, Nahas Neto J, Lera Orsatti C, Vannucchi Portari G, Burini RC. Effects of resistance training frequency on body composition and metabolics and inflammatory markers in overweight postmenopausal women. J Sports Med Phys Fitness. 2014 Jun;54(3):317-25. — View Citation

Maffiuletti NA, Aagaard P, Blazevich AJ, Folland J, Tillin N, Duchateau J. Rate of force development: physiological and methodological considerations. Eur J Appl Physiol. 2016 Jun;116(6):1091-116. doi: 10.1007/s00421-016-3346-6. Epub 2016 Mar 3. Review. — View Citation

Marsh AP, Miller ME, Saikin AM, Rejeski WJ, Hu N, Lauretani F, Bandinelli S, Guralnik JM, Ferrucci L. Lower extremity strength and power are associated with 400-meter walk time in older adults: The InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1186-93. — View Citation

Masson CR, Dias-da-Costa JS, Olinto MT, Meneghel S, Costa CC, Bairros F, Hallal PC. [Prevalence of physical inactivity in adult women in São Leopoldo, Rio Grande do Sul, Brazil]. Cad Saude Publica. 2005 Nov-Dec;21(6):1685-95. Epub 2006 Jan 9. Portuguese. — View Citation

Muscaritoli M, Anker SD, Argilés J, Aversa Z, Bauer JM, Biolo G, Boirie Y, Bosaeus I, Cederholm T, Costelli P, Fearon KC, Laviano A, Maggio M, Rossi Fanelli F, Schneider SM, Schols A, Sieber CC. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clin Nutr. 2010 Apr;29(2):154-9. doi: 10.1016/j.clnu.2009.12.004. Epub 2010 Jan 8. — View Citation

Nunes PR, Barcelos LC, Oliveira AA, Furlanetto Júnior R, Martins FM, Orsatti CL, Resende EA, Orsatti FL. Effect of resistance training on muscular strength and indicators of abdominal adiposity, metabolic risk, and inflammation in postmenopausal women: controlled and randomized clinical trial of efficacy of training volume. Age (Dordr). 2016 Apr;38(2):40. doi: 10.1007/s11357-016-9901-6. Epub 2016 Mar 17. — View Citation

Nunes PR, Barcelos LC, Oliveira AA, Júnior RF, Martins FM, Resende EA, Orsatti FL. Muscular strength adaptations and hormonal responses after two different multiple-set protocols of resistance training in postmenopausal women. J Strength Cond Res. 2017 Jan 20. doi: 10.1519/JSC.0000000000001788. [Epub ahead of print] — View Citation

Nunes PRP, Oliveira AA, Martins FM, Souza AP, Orsatti FL. Effect of resistance training volume on walking speed performance in postmenopausal women: A randomized controlled trial. Exp Gerontol. 2017 Oct 15;97:80-88. doi: 10.1016/j.exger.2017.08.011. Epub 2017 Aug 10. — View Citation

Orsatti FL, Maestá N, de Oliveira EP, Nahas Neto J, Burini RC, Nunes PRP, Souza AP, Martins FM, Nahas EP. Adding Soy Protein to Milk Enhances the Effect of Resistance Training on Muscle Strength in Postmenopausal Women. J Diet Suppl. 2018 Mar 4;15(2):140-152. doi: 10.1080/19390211.2017.1330794. Epub 2017 Jun 12. — View Citation

Orsatti FL, Nahas EA, Maesta N, Nahas-Neto J, Burini RC. Plasma hormones, muscle mass and strength in resistance-trained postmenopausal women. Maturitas. 2008 Apr 20;59(4):394-404. doi: 10.1016/j.maturitas.2008.04.002. Epub 2008 May 21. — View Citation

Orsatti FL, Nahas EA, Orsatti CL, de Oliveira EP, Nahas-Neto J, da Mota GR, Burini RC. Muscle mass gain after resistance training is inversely correlated with trunk adiposity gain in postmenopausal women. J Strength Cond Res. 2012 Aug;26(8):2130-9. — View Citation

Petri Nahas EA, Padoani NP, Nahas-Neto J, Orsatti FL, Tardivo AP, Dias R. Metabolic syndrome and its associated risk factors in Brazilian postmenopausal women. Climacteric. 2009 Oct;12(5):431-8. doi: 10.1080/13697130902718168. — View Citation

Pöllänen E, Sipilä S, Alen M, Ronkainen PH, Ankarberg-Lindgren C, Puolakka J, Suominen H, Hämäläinen E, Turpeinen U, Konttinen YT, Kovanen V. Differential influence of peripheral and systemic sex steroids on skeletal muscle quality in pre- and postmenopausal women. Aging Cell. 2011 Aug;10(4):650-60. doi: 10.1111/j.1474-9726.2011.00701.x. Epub 2011 Apr 12. — View Citation

Poole DC, Burnley M, Vanhatalo A, Rossiter HB, Jones AM. Critical Power: An Important Fatigue Threshold in Exercise Physiology. Med Sci Sports Exerc. 2016 Nov;48(11):2320-2334. Review. — View Citation

Steffen TM, Hacker TA, Mollinger L. Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and gait speeds. Phys Ther. 2002 Feb;82(2):128-37. — View Citation

* Note: There are 24 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Body composition	The body composition will be evaluate by dual-energy X-ray absorptiometry (DXA).	Changes in body composition (e.g. baseline and after 12 weeks of intervention)
Other	Muscle strength	Muscle strength will be assess in all subjects, by the one-repetition maximum (1-RM) test, for dynamic exercises. The 1-RM is defined as the maximal weight that is lifted with proper body alignment and correct lifting technique.	Changes in muscle strength (e.g. baseline and after 12 weeks of intervention)
Primary	Fatigability	The fatigability will be evaluate by 60 maximum voluntary isometric contractions (3 s contraction, 2 s rest) in knee extensors at 70 degree.	Changes in fatigability measure (e.g. baseline and after 12 weeks of intervention)
Secondary	Physical Performance	The physical performance will be evaluate by gait speed tests (e.g. 10m walking at usual and fast pace, 400m walk at usual and fast pace).	Changes in physical performance measure (e.g. baseline and after 12 weeks of intervention)