Protein Supplementation and Mixed Power Training on Muscle Function and Functional Capacities in Elderly Men

Aging Clinical Trial

— PROMU  

Official title:

Effect of Protein Supplementation Combined With Mixed Power Training on Muscle Function, Composition, Phenotype and Functional Capacities Compared to Mixed Power Training Alone in Elderly Men

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03393650
• Other study ID #: UQAM
• Status: Completed
• Phase: N/A
• First received: December 15, 2016
• Last updated: January 2, 2018
• Start date: September 2013
• Est. completion date: December 2015

Study information

• Verified date: January 2018
• Source: Universite du Quebec a Montreal
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Investigate the effect of 12 weeks mixed power training (power and functional exercises) combined with a protein supplementation (30g/d) or not (placebo) on physiological characteristics of muscle and functional capacities in elderly men.

Description:

Life habits are know to be able to prevent the loss of functional capacities and muscle function during aging process. More specifically, protein intake is important to maintain muscle function in older adults. Another non pharmacological intervention and well recognized for its efficacy, it's exercise training.

Recently, it has been observed than muscle quality is more important to maintain physical autonomy than muscle mass per se. In addition, muscle quality is more related to functional capacities than muscle mass.

Due to this recent finding, it has been proposed that muscle power training would be the best exercise intervention to prevent the loss of mobility.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: December 2015
• Est. primary completion date: December 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Elderly men

• 60 years and older

• Sedentary men

• Not obese (BMI <30 kg/m2)

• Living in free-living community

Exclusion Criteria:

• Not able to follow an exercise program (doctor authorization: XAAP)

• Having Lactose intolerance

• Having Pace marker

• Having Metabolism disorder

• No weight stable since the last 6 months

• No stable medication (same dose and type since at least 6 months)

Related Conditions & MeSH terms

• Aging
• Dynapenia
• Physical Impairment

Intervention

Other:
• Exercise + Placebo group
1/2 of the subject will follow a mixed power training: 4 power exercises + 6 functional exercises combined to a placebo
• Exercise + Protein group
1/2 of the subject will receive 30 g/ d of protein (leucine+ vitD; divided in three equal doses: morning, afternoon and evening) + will follow a mixed power training: 4 power exercises + 6 functional exercises.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Universite du Quebec a Montreal

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Change in mitochondrial activity	citrate synthase activity (unit: percent)	Change from Baseline mitochondrial activity at 12 weeks measure in half of the subjects
Primary	Change in walking speed	evaluate using the 4m- normal walking speed (m/sec)	Change from Baseline walking speed at 12 weeks measure in all subjects
Secondary	Change in lower limb muscle quality	Knee extension muscle strength (isometric (N)/ lower limb muscle mass (kg))	Change from Baseline lower limb muscle quality at 12 weeks measure in all subjects