Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Ageing Clinical Trial

— GEP  

Official title:

Human Skin Aging: Clinical Parameters and Gene Expression Profiling

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01451476
• Other study ID #: HSA_GEP
• Secondary ID: 003
• Status: Completed
• Start date: May 2010
• Est. completion date: December 2015

Study information

• Verified date: February 2024
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Skin aging is a complex process involving genetic and environmental factors. The investigators hope to learn more about how human genes and their function can contribute to skin aging and human health.

Description:

This study includes answering a survey on prior sun exposures, donating two small pieces of skin (4mm each), one blood draw, complexion analysis, photographs, and non-invasive tests such as skin surface lipid analysis. Your blood and tissue will be sent for DNA analysis and gene expression profiling.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 122
• Est. completion date: December 2015
• Est. primary completion date: April 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• healthy female, age 18 or older,
• Fitzpatrick type 1 or 2 skin,
• able to read and understand written consent form,
• body mass index normal or overweight range,
• willing to take blood tests and donate skin samples

Exclusion Criteria:

• pregnant or lactating,
• history of cosmetic surgery affecting the face,
• use of prescription anti-aging medications for 2 weeks prior to study,
• use of dietary supplements for 2 weeks prior to study, use of tanning beds or excessive light exposure (>2 hours) in the past 2 weeks,
• medical conditions which at the discretion of the investigator will have significant impact on ability to judge subjects' skin characteristics and age, sunless tanner use in past 2 weeks

Related Conditions & MeSH terms

• Ageing

Locations

Country	Name	City	State
United States	Stanford Dermatology	Redwood City	California

Sponsors (1)

Lead Sponsor	Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

References & Publications (1)

Xu J, Spitale RC, Guan L, Flynn RA, Torre EA, Li R, Raber I, Qu K, Kern D, Knaggs HE, Chang HY, Chang AL. Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. PLoS One. 2016 Nov 9;11(11):e0165913. doi: — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Assessment of age related gene expression changes in skin		Cross sectional