Ageing Clinical Trial
Official title:
Effects of Isoflavone Combined With Astaxanthin on Skin Aging
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the
intrinsic aging process, and accounts for the majority of age-associated changes in skin
appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and
diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous
skin antioxidants as well as plant-derived or synthetic compounds have been examined.
Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were
well-known photo-protective agents with strong antioxidant activity. Several studies have
revealed that supplementation of astaxanthin effectively protect skin against UV damage
through free radicals.
In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step
toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic
and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a
kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1
effectively.
The present study is designed to take isoflavone combined with astaxanthin to maximize their
anti-aging ability and objectively measure the effects of the mixture on facial wrinkles,
hydration, and elasticity.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05534464 -
Protein Digestibility in Older and Younger Adults
|
N/A | |
| Completed |
NCT02796508 -
Attention and Memory Training With Video Games in Old Age
|
N/A | |
| Completed |
NCT02843009 -
Fish Oil and Adaptations to Resistance Exercise in Older People
|
N/A | |
| Active, not recruiting |
NCT04199195 -
Microbiome of the Ageing Gut and Its Effect on Human Gut Health and Cognition.
|
||
| Completed |
NCT02745275 -
Supporting Healthy Aging by Peer Education and Support
|
N/A | |
| Recruiting |
NCT05822154 -
Comprehensive Geriatric Assessment in the Elderly Subjects (PROMISING)
|
||
| Completed |
NCT02575742 -
Colonic Motility in Constipation and Ageing
|
||
| Completed |
NCT02604641 -
Assessment of the Impact of a Coenzyme Q10 Supplementation on the Skin
|
N/A | |
| Active, not recruiting |
NCT01466582 -
Comorbidity and Aging With HIV
|
||
| Enrolling by invitation |
NCT02617719 -
Comprehensive Geriatric Assessment in Primary Care: The Fit for Late Life Project
|
N/A | |
| Completed |
NCT01997320 -
Effect of Strength Training and Protein Supplementation on Muscles in the Very-old
|
N/A | |
| Completed |
NCT02810769 -
The Acute Effect of Two Berry Extracts on Cognition and Mood in Adults Aged 40 to 60
|
N/A | |
| Completed |
NCT01682330 -
The Long-term Effects of Training on Muscle Strength and Functionality
|
N/A | |
| Completed |
NCT02130154 -
Brown Adipose Tissue Activity and Age
|
N/A | |
| Completed |
NCT01451476 -
Human Skin Aging: Clinical Parameters and Gene Expression Profiling
|
||
| Completed |
NCT00176319 -
Leipzig Exercise Intervention in Chronic Heart Failure and Aging
|
Phase 2 | |
| Completed |
NCT02300272 -
Health Behaviors and Time-of-Day: Older Adult Cognitive Function
|
||
| Completed |
NCT02393742 -
Nitrite Supplementation for Improving Physiological Function in Older Adults
|
N/A | |
| Completed |
NCT02603029 -
Influence of of Cream With the Silver Fir Wood Extract (Belinal) on Skin
|
N/A | |
| Completed |
NCT01294137 -
Sleep Apnea in Frail Elderly
|
N/A |