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Adolescent Mood During Puberty and Testosterone — AMPT  

Adolescent Depression Clinical Trial

Official title:
Probing the Neurophysiological Mechanisms Underlying Sex-specific Testosterone-mood Relationships During Puberty: A Randomized Controlled Trial Using a Smartphone-based Training Program

Clinical Trial Summary

Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (ADHD). This divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. The purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06072677
Study type Interventional
Source University of North Carolina, Chapel Hill
Contact Kayla Jensen, BS
Phone 919-445-6815
Email nerdlab@unc.edu
Status Recruiting
Phase N/A
Start date August 24, 2023
Completion date December 2027
View Details
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