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Adiposity clinical trials

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NCT ID: NCT05703802 Completed - Sepsis Clinical Trials

Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.

Start date: February 1, 2022
Phase:
Study type: Observational [Patient Registry]

Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the n-terminus, resulting in a truncated procalcitonin-variant which consists of 114 aminoacids. Within their workgroup the investigators found that the truncated procalcitonin-variant had deleterious effects on vascular integrity during sepsis in mice. However, it is unknown if this applies also in humans. By using an ELISA-assay the investigators want to examine the ratio between native and truncated human procalcitonin during diseases accompanied with hyperprocalcitoninemia and correlate the results with clinical data.

NCT ID: NCT05515016 Completed - Adiposity Clinical Trials

A Fatty Flap Taken From the Double Chin for Chin Enhancement: a New Surgical Technique

Start date: July 2015
Phase: N/A
Study type: Interventional

The double chin is a troublesome component of the lower third of the face. It gives an embarrassing and unpleasant facial appearance to both men and women leading them to ask for liposuction. Moreover, a "receding chin" causes blunting of the cervico-mental angle, a fleshy appearing neck, a disproportion in the profile line of the face with a prominent looking nose, and an irregular mandibular border. This study is about an innovative surgical procedure: Instead of doing liposuction of the double chin, the investigators used the fat of this area as a flap to improve a "receding chin". hence both the double chin and the receding chin are treated.

NCT ID: NCT05387382 Completed - Clinical trials for Bariatric Surgery Candidate

Effects of Bariatric Surgery on Different Compositions of Trunk Fat and Mechanisms

Start date: May 20, 2022
Phase:
Study type: Observational [Patient Registry]

This is a prospective, single-center, observational study to explore effects of bariatric surgery on different compositions of trunk fat and mechanisms.

NCT ID: NCT04980599 Completed - Obesity Clinical Trials

Effect of a Probiotic Strain Lactobacillus Paracasei K56 on Metabolic Symptom - a Pilot Study

Start date: January 10, 2021
Phase: N/A
Study type: Interventional

Recent data suggest that gut microbiota can function as an environmental factor that modulates the amount of body fat and obese individuals have an altered gut microbiota.The results of previous animal studies have suggest that a probiotic strain Lactobacillus paracasei K56 have reduced high-fat diet induced obesity. In this before-after pilot study, the participants were randomly assigned to 8 groups to compare the fat-reducing effect of the Lactobacillus paracasei K56 by continuously supplementing different product prototypes , and screen the best probiotic K56 prototype with the effect of fat reduction.

NCT ID: NCT04841551 Completed - Adiposity Clinical Trials

Kybella for the Treatment of Flank Fat (FF)

Start date: July 22, 2021
Phase: Phase 4
Study type: Interventional

To Determine the safety and Effectiveness of Kybella for the treatment of Flank Fat (FF)

NCT ID: NCT04787952 Completed - Healthy Clinical Trials

Insight Into New Brown Adipose Tissue Activators.

Start date: October 1, 2016
Phase:
Study type: Observational

The general purpose of the study was to provide new information about the role of macronutrients intake, metabolomics, proteomics and microRNA on BAT activation. The invesigator evaluated BAT activity and whole body energy consumption under cold stimulation in two gruops of healthy males aged 21-43 years old with normal BMI ( 19-25kg/m2) and in overweight/obese subjects.

NCT ID: NCT04675255 Completed - Adiposity Clinical Trials

Assessing the Impact of INSTI to PI Switch on Insulin Sensitivity and Fat Metabolism

ADIPOSITY
Start date: January 1, 2021
Phase: N/A
Study type: Interventional

A substudy of TMC114FD2HTX4004 that will perform glucose tolerance testing, adipose testing and MRI scan at baseline, 12 and 24 weeks post switch of ART medications.

NCT ID: NCT04613700 Completed - Obesity Clinical Trials

The Role of Secretin on the Energy Homeostasis

THE-ROSE
Start date: March 1, 2020
Phase: N/A
Study type: Interventional

As of last year, new insight into the function of secretin was brought about as rodent studies showed secretin to possess potential body weight-regulating effects. In these studies, secretin was shown to increase non-shivering thermogenesis in brown adipose tissue (BAT), decrease meal size and promote meal discontinuation. The mechanisms behind these regulatory effect of secretin on energy homeostasis are unclear,

NCT ID: NCT04182542 Completed - Adiposity Clinical Trials

Effects of Capacitive Radiofrequency at the Dermis and Adipose Tissue

Start date: December 2, 2019
Phase: N/A
Study type: Interventional

Noninvasive fat reduction is a rapidly expanding field of cosmetic rejuvenation, as many patients are unwilling to suffer the downtime and healing associated with traditional invasive liposuction. The radiofrequency (RF) device has been shown to be safe and effective for non-invasive fat reduction, as well as cutaneous enhancement and improvement of skin flaccidity (BOISNIC, et al., 2014).

NCT ID: NCT04054011 Completed - Adiposity Clinical Trials

Safety and Efficacy of Deoxycholic Acid Injection for Reduction of Upper Inner Thigh Fat

Start date: July 5, 2019
Phase: Early Phase 1
Study type: Interventional

This is a phase I, open-label clinical trial evaluating the safety and efficacy of deoxycholic acid injection for reduction of upper inner thigh fat.