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Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea

OSA Clinical Trial

Official title:
Effect of Opioids on Central Control of Ventilation in Children With Obstructive Sleep Apnea

Clinical Trial Summary

Children OSA exhibit varying responses to opioids. It is unknown if the degree of intermittent hypoxemia results in different opioid sensitivity

Clinical Trial Description

Ventilatory suppression in children following opioid administration is of obvious concern, especially following routine surgical procedures (i.e. adenotonsillectomy). It is thought that patients with obstructive sleep apnea (OSA) have increased sensitivity to opioids, and especially in opioid naïve patients. Recent evidence in children suggests that patients with moderate to severe OSA may not predispose patients to increased opioid sensitivity in the form of respiratory depression when compared with patients that do not have OSA. However, what is not known is wether the degree of hypoxemia experienced by patients effects the opioid sensitivity. The aim of this study is to identify if children with known OSA experience a difference in opioid induced respiratory depression based on the degree of hypoxemia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05051189
Study type Interventional
Source Baylor College of Medicine
Contact
Status Recruiting
Phase Early Phase 1
Start date December 1, 2021
Completion date November 1, 2024
View Details
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