Chemoprevention of Colorectal Adenomas

Status Terminated

Clinical Trial Summary

The purpose of the study is to investigate if long-term treatment with three known drugs (acetylsalicylic acid, 1α 25-dihydroxy cholecalciferol, and calcium carbonate) prevents recurrence of colorectal adenomas.

Clinical Trial Description

This is a multicenter, randomized, parallel group, prospective, double blind, placebo controlled clinical trial of chemoprevention in patients at increased risk of developing colorectal cancer (CRC). The Colotech combination treatment (acetylsalicylic acid, 1α 25-dihydroxy cholecalciferol, and calcium carbonate) will be compared to placebo with regards to safety and efficacy during 3 years of treatment. The randomized treatment period will be preceded by a 3-week single blind placebo run-in period, which will assess patient's compliance to treatment. In order to collect data on the durability of treatment effect, follow-up data from a surveillance colonoscopy will be collected two years after the 3-year colonoscopy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00486512
Study type	Interventional
Source	Colotech A/S
Contact
Status	Terminated
Phase	Phase 3
Start date	June 2007
Completion date	November 2010

View Details

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