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Adenomatous Polyposis Coli clinical trials

View clinical trials related to Adenomatous Polyposis Coli.

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NCT ID: NCT06435533 Recruiting - Clinical trials for Familial Adenomatous Polyposis

Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis

coldAPC
Start date: December 6, 2023
Phase: N/A
Study type: Interventional

The objective of this study is to investigate the feasibility for the treatment of precancerous peri-ampullary FAP polyps in the duodenum using low-thermal argonplasma.

NCT ID: NCT06163365 Recruiting - Lynch Syndrome Clinical Trials

Inherited Cancer Early Diagnosis (ICED) Study

ICED
Start date: July 26, 2022
Phase:
Study type: Observational [Patient Registry]

ICED is a prospective sample collection research study, aiming to develop or validate a blood/urine biomarker which could potentially detect cancers early in individuals at high risk of developing cancers, due to certain germline alterations.

NCT ID: NCT06005974 Recruiting - Solid Tumor Clinical Trials

A Study of REC-4881 in Participants With Cancers Which Have an AXIN1 or APC Mutation

Start date: January 15, 2024
Phase: Phase 2
Study type: Interventional

This is a multi-center, open-label study to investigate the safety, efficacy and pharmacokinetics of REC-4881 (12 mg PO daily doses) for the treatment of participants with unresectable locally advanced or metastatic solid tumors with AXIN1 or APC mutation.

NCT ID: NCT05919264 Recruiting - Cancer Clinical Trials

FOG-001 in Locally Advanced or Metastatic Solid Tumors

Start date: May 19, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer.

NCT ID: NCT05552755 Recruiting - Clinical trials for Familial Adenomatous Polyposis

Evaluate REC-4881 in Patients With FAP

TUPELO
Start date: July 10, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

This is a multicenter, two-part trial in participants with Familial Adenomatous Polyposis (FAP).

NCT ID: NCT05420064 Recruiting - BRCA1 Mutation Clinical Trials

An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate a cascade genetic testing intervention. Cascade testing is the process of offering genetic testing to people who are at risk of having inherited a possibly harmful gene change that has been found in their family. This process is repeated as more people within the family are found to have the gene change. The study will look at how often genetic testing occurs when healthcare providers have permission to reach out to family members to recommend genetic testing and to help those who are interested get tested. The study will look at whether this cascade testing intervention is practical and effective. The study would like to see how this approach of healthcare providers reaching out directly to family members compares with the usual approach of patients telling their family members about the recommendation to get genetic testing.

NCT ID: NCT05223036 Recruiting - Clinical trials for Colorectal Carcinoma

Testing Obeticholic Acid for Familial Adenomatous Polyposis

Start date: January 19, 2023
Phase: Phase 2
Study type: Interventional

This phase IIa trial investigates if giving obeticholic acid (OCA) is safe and has a beneficial effect on the number of polyps in the small bowel and colon in patients with familial adenomatous polyposis (FAP). FAP is a rare gene defect that increases the risk of developing cancer of the intestines and colon. OCA is a drug similar to a bile acid the body makes. It is fluid made and released by the liver. OCA binds to a receptor in the intestine that is believed to have a positive effect on preventing cancer development. OCA has been effective in treating primary biliary cholangitis (PBC), a liver disease, and is approved by the Food and Drug Administration (FDA) for use at a lower dose (10 mg). There have been studies showing that OCA decreases inflammation and fibrosis. However, it is not yet known whether OCA works on reducing the number of polyps in patients with FAP.

NCT ID: NCT04865601 Recruiting - Colorectal Cancer Clinical Trials

DNA Adductomics for Colorectal Cancer Investigation

adductomics
Start date: February 15, 2021
Phase:
Study type: Observational

This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls. In addition, surrogate samples such as white blood cells are investigated for the presense of adducts while blood plasma and urine are investigated for the presense of DNA-repair products.

NCT ID: NCT04709445 Recruiting - Ulcerative Colitis Clinical Trials

Perfusion Rate Assessment by Near-infrared Fluorescence in Gastrointestinal Anastomoses

Start date: March 1, 2020
Phase: N/A
Study type: Interventional

In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at two to three time points during procedures of upper GI, lower GI and hepatobiliary surgery with anastomosis formation in open or laparoscopic surgery. Postoperatively, a detailed software-based assessment of each recording is performed to determine the objective ICG-NIRF perfusion rate before and after anastomosis formation, which is then correlated with the 30 day postoperative clinical outcome including occurrence of anastomotic leak.

NCT ID: NCT04695964 Recruiting - Colorectal Cancer Clinical Trials

Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

Start date: February 1, 2019
Phase: N/A
Study type: Interventional

In this prospective, non-randomized cohort study, real-time intraoperative visualization using near-infrared-fluorescence by indocyanine green injection (ICG-NIRF) is performed at three time points during ileal pouch reconstruction. Postoperatively, a detailed software-based assessment of each pouch recording is performed to determine the objective ICG-NIRF perfusion rate, which is then correlated with the 30 day postoperative clinical outcome including occurrence of anastomotic leak of the pouch.