Acute Pain Clinical Trial
Official title:
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression in Volunteers
Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals during the infusion and a 25-minute recovery period afterwards. After a washout period, the experiment will be repeated in each subject (second run). The two runs differ only by presence versus absence of verbal interaction.
Healthy volunteers aged 20-55 will receive a weight-based opioid (remifentanil) infusion for
10 minutes. Vital signs including SpO2, transcutaneous CO2, and respiratory rate will be
continuously measured.
In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be
taken at baseline, and at 2.5-minute intervals during the infusion and a 25-minute recovery
period afterwards. After a washout period, the experiment will be repeated in each subject
(second run). The two runs differ only by presence of ongoing verbal interaction versus
complete avoidance of verbal interaction.
Incidence of respiratory depression will be compared in the two protocols with or without
verbal interaction. Correlation between pupil diameter and pupillary unrest with estimated
opioid concentrations will be determined by regression. Difference between pupil measurement
versus opioid concentration regressions will be compared by chi2.
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