LY3214996 in Patients With AML Who Are Not Candidates for Standard Therapy

Status Recruiting

Clinical Trial Summary

This research study is evaluating a targeted therapy as a possible treatment for acute myeloid leukemia (AML) that has returned or not responded to standard treatment.

Clinical Trial Description

This research study is a Phase I clinical trial, which tests the safety of an investigational drug and also tries to define the appropriate dose of the investigational drug to use for further studies. "Investigational" means that the drug is being studied. The U.S. Food and Drug Administration (FDA) has not approved LY3214996 as a treatment for any disease. LY3214996 is an extracellular signal-regulated kinase (ERK) inhibitor that is being developed as a treatment for patients with advanced cancer. ERK inhibitors stop the signal that a cancer cell receives telling it to grow. In this research study, the investigators are testing to see if LY3214996 is a safe treatment for AML that has returned or not responded to standard treatment. Several doses of the study drug will be explored in this study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04081259
Study type	Interventional
Source	Dana-Farber Cancer Institute
Contact	Rahul Vedula, MD
Phone	617) 632-5435
Email	rahul_vedula@dfci.harvard.edu
Status	Recruiting
Phase	Phase 1
Start date	July 15, 2020
Completion date	April 30, 2025

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