Acute Myeloid Leukemia Clinical Trial
Official title:
A Study of Prognostic Values of Next Generation Sequencing (NGS) in Acute Myeloid Leukemia Patients With Allo-HSCT
Acute myeloid leukemia (AML) is a genetically heterogeneous disease and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for AML except for AML-M3. Relapse remains the major cause of treatment failure after allo-HSCT. Molecular residual disease has been shown to be a strong risk factor for relapse after HSCT. In this study, the investigators will detect mutations before/after allo-HSCT by using next-generation sequencing (NGS) technique to measure residual disease and evaluate the prognostic impact of molecular residual disease in a cohort of AML participants receiving allo-HSCT.
Status | Not yet recruiting |
Enrollment | 500 |
Est. completion date | October 15, 2021 |
Est. primary completion date | October 15, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - 18 years or old; - Clinical diagnosis of acute myeloid leukemia (AML); - Availabe records of MICM and NGS results at diagnosis; - Be going to receive allo-HSCT. Exclusion Criteria: - Active malignancy; - Pregnant or breast feeding women. |
Country | Name | City | State |
---|---|---|---|
China | The First affiliated Hospital of SooChow University | Suzhou | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
The First Affiliated Hospital of Soochow University |
China,
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* Note: There are 25 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | 1-year relapse rate after allo-HSCT | 1-year relapse rate after allo-HSCT | 1 year after allo-HSCT | |
Secondary | 1-year recurrence-free survival (RFS) | 1-year recurrence-free survival for AML participants | 1 year after allo-HSCT | |
Secondary | 1-year overall survival (OS) | 1-year overall survival (OS) for AML participants | 1 year after allo-HSCT |
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