Acute Myeloid Leukemia Clinical Trial
Official title:
Multi-center Phase I/II Clinical Trial of Multi-CAR T Cell Therapy for Acute Myeloid Leukemia
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of multi-CAR T cell therapy targeting different AML surface antigens in patients with relapsed or refractory acute myeloid leukemia (AML). Another goal of the study is to learn more about the function of the multi-CAR T cells and their persistency in the patients.
Acute myeloid leukemia (AML) is a malignant disease characterized by the rapid growth of
myeloblasts that build up in the bone marrow and interfere with the production of normal
blood cells.
In this study, the patients' own T cells will be genetically modified with lentiviral vectors
expressing chimeric antigen receptors. The multi-CAR T cells recognize specific molecules
such as CD33, CD38, CD123, CD56, MucI, and CLL1, which are often found expressed on the
surface of AML cells. The engineered CAR T cells will be infused into patients.
The purpose of this clinical study is to assess the feasibility, safety and efficacy of the
multi-CAR T cell therapy against AML. Another goal of the study is to learn more about the
function of the multi-CAR T cells and their persistency in the patients.
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