Acute Myeloid Leukemia Clinical Trial
Official title:
A Multicenter,Open-label,Radonmized Study on the Treatment of Older Adult Acute Myeloid Leukemia Patients Aged 55 to 65 Years Old
The purpose of this study is to determine whether the escalation dosage of Daunorubicin and cytarabine is effective and safety in the treatment of older adult Chinese acute myeloid leukemia(AML) patients aged 55 to 65 years.
the DA 3+7 regimen is the standard therapy in the AML treatment.Escalated dosage of
daunorubicin in induction therapy is reported effective and result in a more rapid response
and a higher response rate than does the conventional dose, without additional toxic effects
in elderly AML patients between 60 to 65 years.Higher Overall survival rate and Event-free
survival rate was obtained in escalated group compared with conventional dose. We are
wondering if Chinese older AML patients can benefit from this escalated induction regimen.
High dose cytarabine in AML consolidation is reported improving the survival of elderly AML
patients than the conventional dose,but it is not determined in Chinese older adult AML
patients.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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