Epigenetic Reprogramming in Relapse/Refractory AML

Status Completed

Clinical Trial Summary

This is a pilot study using decitabine and vorinostat before and during chemotherapy with fludarabine, cytarabine and G-CSF (FLAG).

Clinical Trial Description

Decitabine is a demethylating agent and vorinostat is a HDAC inhibitor. The use of demethylating agents and HDAC inhibitors in combination have been previously shown to have synergistic effects in altering neoplastic pathways of cancer cells and be well tolerated in human clinical studies. With the ability of decitabine and vorinostat to alter the abnormal cellular pathways of leukemic blasts and essentially turn off anti-apoptotic proteins, the leukemia cells have become primed for cytotoxic cell kill via chemotherapeutic agents. This study will ask the question as to whether or not the combination of decitabine and vorinostat followed by chemotherapy is feasible and whether it can positively impact outcome in patients with relapsed or refractory acute myelogenous leukemia. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03263936
Study type	Interventional
Source	Therapeutic Advances in Childhood Leukemia Consortium
Contact
Status	Completed
Phase	Phase 1
Start date	July 11, 2017
Completion date	February 10, 2022

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