Acute Myelogenous Leukemia Clinical Trial
Official title:
Phase II Clinical and Pharmacodynamic Investigation of Clofarabine in Acute Leukemias
The goals and objectives of this project are to evaluate the antileukemic activity of the investigational agent clofarabine in patients with acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myelogenous leukemia (CML) in accelerated and blastic phases.
The specific aims of the project are (1) conduct the phase II study of clofarabine and
evaluate the antileukemic efficacy in AML, ALL, and CML-accelerated and blastic phases in
terms of complete response (CR) rate, response duration, and survival; and (2) analyze the
relationship between cellular uptake and retention of clofarabine triphosphate (the active
metabolite), inhibition of DNA synthesis, and clinical outcome.
Completion date provided represents the completion date of the grant per OOPD records
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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