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Clinical Trial Summary

This is a phase II clinical study to evaluate the safety and efficacy of pCAR-19 B cell autologous infusion preparation in the treatment of CD19-positive relapsed/refractory B-cell acute lymphoblastic leukemia.


Clinical Trial Description

This is a multiple-center, single-arm, open-label study. After meeting the eligibility criteria and enrolling on the trial, patients will undergo leukapheresis for collection of autologous lymphocytes. Once cells have been manufactured, patients will then proceed to lymphodepleting chemotherapy with cyclophosphamide 300mg/m2 and fludarabine 30mg/m2 for 3 consecutive days followed by the infusion of CD19 CAR T-cells at a target dose of 0.6-2 x106 cells/kg. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05334823
Study type Interventional
Source Chongqing Precision Biotech Co., Ltd
Contact Tianyou Wang, M.D
Phone 010-59616161
Email wangtianyou@bch.com.cn
Status Recruiting
Phase Phase 2
Start date January 26, 2022
Completion date July 1, 2025

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