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Clinical Trial Summary

For micro residual disease (MRD) positive patients who have undergone at least 2 cycles chemotherapies for their CD19+ B-cell malignancies, there would be much more risks for them to receive hematological stem cell transplantation (HSCT) than MRD- patients. In order to reduce HSCT-related adverse events for these kind of patients, investigators plan to conduct CAR-T therapies on them first to make them achieve MRD- statuses, and then transfer them to HSCT.


Clinical Trial Description

In order to improve prognoses for MRD+ patients who have undergone at least 2 cycles chemotherapies, patients will receive CAR-T therapy before HSCT, once they achieve MRD- remissions, they will subsequently receive HSCT if there are no contraindications. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03366324
Study type Interventional
Source Wuhan Sian Medical Technology Co., Ltd
Contact YU HU, M.D., Ph.D
Phone 86-13986183871
Email dr_huyu@126.com
Status Recruiting
Phase Phase 1/Phase 2
Start date May 1, 2016
Completion date June 1, 2021

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