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Clinical Trial Summary

Patients with acute leukemia relapsing after allotransplant and who respond to anti-leukaemia interventions are at high-risk of a second relapse. Previous studies from investigators reported an association between a positive minimal residual disease (MRD)-test after transplant and an increased risk of subsequent relapse. Also, patients developing chronic graft-versus-host disease (GvHD) after receiving DLI (donor lymphocyte infusion)for leukemia relapse after a first allotransplant have a lower likelihood of a second relapse compared with similar patients not developing chronic GvHD. And, our previous study also reported patients with chronic GvHD after DLI was associated with a greater frequency of a negative MRD-test and lower likelihood of subsequent relapse compared with similar persons not developing chronic GvHD. Based on these data the investigators designed a randomized control study to determine whether giving additional consolidation chemotherapy and DLI might decrease likelihood of second relapse in persons without chronic GvHD or with a positive MRD-test after initial post-relapse therapy with induction chemotherapy and DLI.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03297528
Study type Interventional
Source Peking University People's Hospital
Contact Chen-hua Yan, Dr
Phone 8610-82816999
Email yanchenhua@vip.sina.com
Status Recruiting
Phase Phase 2
Start date March 1, 2017
Completion date October 1, 2021

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