Identification of Patient Phenotypes Associated With Elevated Aldosterone Levels

Acute Heart Failure Clinical Trial

Official title:

Identification of Patient Phenotypes Associated With Elevated Aldosterone Levels

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01614860
• Other study ID #: KL2-2012NWAHF
• Secondary ID: KL2RR025740
• Status: Completed
• Phase: N/A
• First received: June 6, 2012
• Last updated: September 7, 2014
• Start date: May 2012
• Est. completion date: June 2014

Study information

• Verified date: September 2014
• Source: Northwestern University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Post-discharge mortality and re-hospitalization for acute heart failure (AHF) affects 15% and 30% of patients respectively, within 90 days. With over 1 million annual hospitalizations and a financial cost exceeding 20 billion dollars, AHF is a major public health burden. Yet no AHF therapy to date definitively reduces morbidity and mortality, and in stark contrast to heart attack patients, highly rated evidence in guidelines do not exist. Although AHF is a syndrome and not one disease, typical treatment of patients hospitalized with AHF suggests otherwise. Despite substantial differences among AHF patients, therapy is largely uniform; patients receive medicine to help get rid of excess volume and little else. Although decades of empirical use support the symptomatic benefits of traditional therapies, outcomes remain extremely poor. As opposed to the "one-size-fits-all‟ approach used unsuccessfully to date in clinical trials, identification of specific AHF patient sub-groups is critical, so that tailored therapies can be developed and tested. Preliminary data suggests that the neurohormone aldosterone may be detrimental in AHF patients. Furthermore, this hormone level appears to rise during hospitalization. The investigators therefore propose to identify specific AHF patient phenotypes associated with high serum aldosterone levels to subsequently address the hypothesis that early aldosterone blockade continued throughout hospitalization will decrease re-hospitalization and mortality. Specifically, the investigators hypothesize that AHF patients with elevated serum aldosterone levels have a distinct phenotype compared to those with lower or normal aldosterone levels. Specifically, they will be older, have a lower systolic blood pressure, lower EF, worse renal function, higher BNP, and previous hospitalization for HF.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. completion date: June 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion criteria:

• Male or female = 18 years of age

• AHF is the primary working diagnosis for ER management and treatment Have received or will receive IV diuretic therapy

• Enrolled within 12 hours of initial diuretic dose order

Exclusion criteria:

• Serum Cr = 2.5mg/dL (males) or 2.0mg/dL (females), or eGFR < 20 ml/min/1.73m2

• Serum potassium = 5.5 mEq/L

• Transplant recipients of any kind

• Fever > 101.0

• Severe lung disease (required home O2 or daily oral steroids)

• Acute coronary syndrome within last 30 days

• Major surgery within last 30 days

• Known hypertrophic obstructive cardiomyopathy, pericardial constriction, or hemodynamically significant valvular disease

• Life expectancy less than 12 months for any reason

• Current treatment for any malignancy of any kind

• Cardiogenic shock and/or requiring IV inotropic therapy

• Pregnant or recently pregnant within last 90 days

• Known intolerance to aldosterone antagonist

• Inability to give appropriate written consent

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acute Heart Failure

Locations

Country	Name	City	State
United States	Northwestern Memorial Hospital	Chicago	Illinois

Sponsors (2)

Lead Sponsor	Collaborator
Northwestern University	National Center for Research Resources (NCRR)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	To prospectively examine the baseline and dynamic phenotype of AHFS patients in relation to aldosterone levels on initial presentation.	Hypothesis 2.1: The "high aldosterone" phenotypic profile identified in Aim 1 will be associated with high aldosterone levels on initial presentation to the ER in our prospective replication study.; Hypothesis 2.2: AHFS patients with high aldosterone levels on presentation will have increased high-sensitivity troponin release and echocardiographic markers of increased myocardial and atrial fibrosis.; Hypothesis 2.3: Repeat examination at 48 hours after initial presentation will demonstrate lack of improvement in laboratory and echocardiographic biomarkers of congestion, myocyte injury, and fibrosis in AHFS patients with high aldosterone levels, suggesting a time-sensitive component to aldosterone antagonism in AHFS.	two years	No
Primary	There is no prespecified primary outcome as this is an exploratory study		2 years	No
Secondary	There is no secondary outcome as this is an exploratory study		2 years	No