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Acute Heart Failure clinical trials

View clinical trials related to Acute Heart Failure.

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NCT ID: NCT03234647 Completed - Acute Heart Failure Clinical Trials

First In Human Study of the Doraya Catheter for the Treatment of AHF Patients

Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Safety and performance evaluation of the Doraya catheter in patients admitted with AHF.

NCT ID: NCT03110042 Completed - Acute Heart Failure Clinical Trials

HILO-HF Registry: High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

Start date: November 2016
Phase:
Study type: Observational [Patient Registry]

The HILO-HF Registry is a single centre registry that will be performed to provide information on the usual baseline oxygen saturation (SpO2) in patients presenting to ED with a primary ED diagnosis of AHF

NCT ID: NCT03048032 Completed - Acute Heart Failure Clinical Trials

Lithuanian Echocardiography Study of Dyspnea in Acute Settings

LEDA
Start date: April 2015
Phase:
Study type: Observational

LEDA (Lithuanian Echocardiography study of Dyspnea in Acute settings) is a prospective observational cohort multicenter clinical study. Project is carried out by Vilnius University together with a partner Lithuanian University of Health Sciences, in conjunction with a research protocol of international GREAT consortium (Global Research on Acute Conditions Team). The aim of this project is to find the specific novel biomarkers of acute heart failure (AHF), to evaluate their diagnostic and prognostic role in association with echocardiographic parameters of AHF. Primary endpoint is 1-year all-cause mortality and rehospitalization. Secondary endpoints are 1) in-hospital all-cause mortality 2) post-discharge 1 and 3 month all-cause mortality and rehospitalization 3) post-discharge 1 and 3 month cardiovascular mortality and rehospitalization 4) one-year cardiovascular mortality and rehospitalization. During the project a sizeable national database (2000 Lithuanian patients) will be integrated into database of GREAT network. Novel cardiac biomarkers together with ultrasound parameters of right ventricular (RV) function are in the focus of the study. During the acute phase of heart failure, up to 15 novel cardiac, vascular, renal impairment and inflammation biomarkers in plasma samples will be investigated in Lithuania and France (INSERM laboratory). Plasma samples will be taken during 4 hours after admission and frozen at -80ºC to allow batch analysis. The extensive evaluation of innovative ultrasound parameters of right ventricular structure and function will be performed in the early hospitalization period, along with standard echocardiography examination. The first database of AHF patients in Lithuania will provide demographic data and trends of morbidity and mortality, as well as analysis of diagnostic and prognostic value of novel biomarkers and echocardiography parameters in the Baltic region. Quantitative parameters of RV systolic function and deformation will be measured. It is expected that optimal use of novel biomarkers and reproducible echocardiography parameters in the setting of emergency and critical care would reduce unnecessary hospitalizations, cost and hospital length of stay without decrease in the quality of diagnostics and treatment. An estimation of correlation of echocardiographic parameters and biomarkers could help create an accurate algorithm for risk stratification and diagnosis of AHF in an emergency setting.

NCT ID: NCT02877095 Completed - Acute Heart Failure Clinical Trials

Subcutaneous Furosemide in Acute Decompensated Heart Failure Pilot

SUBQ-Pilot
Start date: December 19, 2016
Phase: Phase 1
Study type: Interventional

The Pilot study is designed to evaluate the overall safety and feasibility of a strategy based on subcutaneous delivery of furosemide. It will be used to inform the subsequent evaluation phase of the study (separate protocol). The primary objective of the study is to determine if a strategy of a novel subcutaneous delivery of furosemide is safe and feasible in patients with acute heart failure.

NCT ID: NCT02782572 Completed - Heart Failure Clinical Trials

Safety of Aerobic Exercise in Acute Heart Failure

Start date: July 2010
Phase: N/A
Study type: Interventional

This project deals with exercise in acute heart failure in three different groups (conventional medical treatment; exercise with non-invasive ventilation and exercise with placebo of non-invasive ventilation).

NCT ID: NCT02728739 Completed - Clinical trials for Mitral Regurgitation

Incidence of Significant Mitral Regurgitation in Acute Heart Failure Patients

MRAHF
Start date: June 6, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to determine the prevalence of moderate-to-severe Mitral Regurgitation (MR) in acute Heart Failure (HF) patients requiring hospital admission.

NCT ID: NCT02554890 Completed - Acute Heart Failure Clinical Trials

Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.

PIONEER-HF
Start date: April 29, 2016
Phase: Phase 4
Study type: Interventional

The purpose of this study was to assess the effect of in-hospital initiation of sacubitril/valsartan (LCZ696) vs. enalapril on time averaged proportional change in NT-proBNP in patients who have been stabilized following hospitalization for acute decompensated heart failure (ADHF) and reduced ejection fraction (left ventricular ejection fraction (LVEF) ≤ 40%).

NCT ID: NCT02350114 Completed - Acute Heart Failure Clinical Trials

An Observational Study of the Functional Capacity of Heart Failure

Start date: November 2014
Phase: N/A
Study type: Interventional

This is an observational study of the functional capacity of patients with Heart failure with Reduced Ejection Fraction (HFrEF) who are admitted to the hospital for routine medical treatment.

NCT ID: NCT02170961 Completed - Acute Heart Failure Clinical Trials

Study of Polymorphisms of RAAS and MMPs in Acute Heart Failure

PRA-MMP
Start date: February 2013
Phase:
Study type: Observational

this study aim to investigate the: - association of RAAS polymorphisms and AHF - association of MMP 3 and 12 polymorphisms and AHF

NCT ID: NCT02157506 Completed - Heart Failure Clinical Trials

A Dose Ranging Phase IIa Study of 6 Hour Intravenous Dosages of CXL-1427 in Patients Hospitalized With Heart Failure

Start date: June 30, 2014
Phase: Phase 2
Study type: Interventional

A randomized, double-blinded, placebo-controlled study of continuous 6-hour IV infusions of CXL-1427 in hospitalized patients with systolic heart failure.