Clinical Trials Logo
  1. Home
  2. Acute Coronary Syndromes
  3. NCT06089343

High-risk Features of Coronary Lesions in CTA and OCT

Acute Coronary Syndromes Clinical Trial

Official title:
Exploring the High-risk Features of Coronary Lesions Using CT Angiography and Optical Coherence Tomography

Clinical Trial Summary

This study is a multicenter and retrospective study. ACS patients who underwent CCTA or OCT from 1 months to 3 years prior to the event will be retrospectively identified. Plaques in the non-culprit vessels will be regarded as a primary control group.

Clinical Trial Description

The high-risk features of plaque rupture and subsequent acute coronary syndrome (ACS) are not fully identified. Plaque features, hemodynamic forces, and the interaction between these factors may cause plaque instability and subsequent clinical events. A previous study showed that the addition of hemodynamic parameters calculated noninvasively from coronary computed tomography (CCTA) using computational fluid dynamics (such as wall shear stress and axial plaque stress) improved the ability to predict the risk of ACS compared with conventional approaches based on anatomical stenosis severity and adverse plaque characteristics. Wall shear stress and axial plaque stress derived from CT were highly correlated to those derived from optical coherence tomography (OCT). In addition, other hemodynamic parameters, such as oscillatory shear index, endothelial shear stress (ESS), and spatial ESS gradient have also been demonstrated to be associated with unstable plaque. In this regard, we designed this study to find the best hemodynamic and plaque features derived from CTA and verified by OCT to predict ACS, and to investigate whether a comprehensive risk prediction model with them has an incremental value in a larger population. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06089343
Study type Observational
Source Shanghai Zhongshan Hospital
Contact
Status Active, not recruiting
Phase
Start date October 1, 2023
Completion date October 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT02552407 - Thrombectomy in ST Elevation Myocardial Infarction, an Individual Patient Meta-analysis N/A
Completed NCT01398228 - Clinical Pathways for the Management of Acute Coronary Syndromes - Phase 3,CPACS-3 N/A
Completed NCT01135667 - Prasugrel Versus Double Dose Clopidogrel to Treat Clopidogrel Low-responsiveness After PCI Phase 4
Recruiting NCT02592720 - Cocktail Injection Improves Outcomes of FFR Guided PCI Phase 4
Completed NCT01641510 - PRAsugrel or clopIdogrel In Acute Coronary SyndromE With CYP2C19 GENEtic Variants Phase 3
Completed NCT01743274 - Does Optical Coherence Tomography Optimise Results of Stenting N/A
Active, not recruiting NCT01433627 - Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX Phase 3
Completed NCT01452282 - Ankle-Brachial Index Estimating Cardiac Complications After Surgery N/A
Recruiting NCT01418794 - Efficacy and Safety of the YUKON Drug Eluting Stent in Diffuse Coronary Artery Disease Phase 4
Recruiting NCT01000701 - Inflammation and Acute Coronary Syndromes N/A
Terminated NCT01107899 - Study to Learn When Platelets Return to Normal After One Loading Dose of Anti-platelet Drugs in Patients With Symptoms of Acute Coronary Syndromes Phase 1
Completed NCT00494247 - Endothelial Progenitor Cells-capture Stents in Acute Coronary Syndromes Phase 4
Terminated NCT00615719 - Computed Tomographic Coronary Angiography for Acute Chest Pain Evaluation N/A
Not yet recruiting NCT04023630 - DUAL Antithrombotic Therapy in Patients With AF and ACS Phase 4
Recruiting NCT02601404 - REal World Advanced Experience of BioResorbable ScaffolD by SMart Angioplasty Research Team (SMART REWARD) N/A
Completed NCT02195193 - Integrating Depression Care in Acute Coronary Syndromes Care in China N/A
Completed NCT02141750 - THIRD NATIONAL REGISTRY OF ACUTE CORONARY SYNDROMES N/A
Not yet recruiting NCT01735227 - Omeprazole and Pantoprazole Antiplatelet Effect of Clopidogrel Clinical Trials(OPEN) Phase 4
Completed NCT00097591 - A Comparison of Prasugrel (CS-747) and Clopidogrel in Acute Coronary Syndrome Subjects Who Are to Undergo Percutaneous Coronary Intervention Phase 3
Completed NCT02725099 - Chewing Versus Traditional Oral Administration of Ticagrelor in STEMI Patients Phase 4