Electrolytes in Chronic Kidney Disease Patients With Acute Coronary Syndrome

Acute Coronary Syndrome Clinical Trial

Official title:

Study of Serum Calcium and Phosphorus Level in Chronic Kidney Disease Patients With Acute Coronary Syndrome

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05134220
• Other study ID #: Electrolytes
• Status: Recruiting
• Start date: November 30, 2021
• Est. completion date: May 30, 2022

Study information

• Verified date: November 2021
• Source: Sohag University
• Contact: Ahmed M YOUSEF, M.B.B.CH
• Phone: 01067439846
• Email: ahmed011032[@]med.sohag.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.

Description:

Prospective study to :

1. find the relation between electrolytes disturbance and renal diseases

2. the effect of electrolyte abnormalities on atherosclerosis

3. prevalence of acute coronary syndrome in patients with chronic kidney disease

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: May 30, 2022
• Est. primary completion date: May 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 1-The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features :

a- Electrocardiogram (ECG) changes:

• ST elevation.

• ST depression.

• T wave inversion.

• recent left bundle branch block.

b- Troponin T elevation.

2-The CKD patient with or without dialysis with no previous history of ACS.

Exclusion Criteria:

1. Patients who were diagnosed with primary hyperparathyroidism.

2. Acute Kidney injury (AKI) which is defined as any of the following:(KDIGO2012)

• Increase in S.Cr by = 0.3 mg/dl (= 26.5 µmol/l) within 48hours; or

• Increase in S.Cr to = 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days;or

• Urine volume <0.5 ml/kg/h for 6 hours

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Kidney Diseases
• Renal Insufficiency, Chronic
• Syndrome

Intervention

Diagnostic Test:
• Serum Calcium
Serum calcium level. Serum phosphorus level. will be measured to all study population

Locations

Country	Name	City	State
Egypt	Sohag university	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Block GA, Hulbert-Shearon TE, Levin NW, Port FK. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis. 1998 Apr;31(4):607-17. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Chronic kidney disease hospitalization	The CKD patient with and without acute coronary syndrome and estimated hazard ratios (HR) by use of multivariable Cox regression models.	from the day of admission to the day of discharge through study completion, an average of 28 weeks, in sohag university hospital