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Colchicine for the Stability of Coronary Plaque in Acute Coronary Syndrome (COLOCT) — COLOCT  

Acute Coronary Syndrome Clinical Trial

Official title:
The Efficacy and Safety of Colchicine in Improving the Stability of Coronary Plaque in Patients With Acute Coronary Syndrome

Clinical Trial Summary

Evidence from the COLCOT Trial has shown that anti-inflammatory effect of colchicine reduced the risk of cardiovascular events in patients with recent myocardial infarction. We hypothesized that this might be due to the improvement of the coronary plaque stability by colchicine. Optical coherence tomography (OCT) is the most precise method to detect plaque stability in clinical practice. Thus, the purpose of this study is to evaluate the efficacy and safety of colchicine on improving the stability of coronary plaque in patients with acute coronary syndrome.

Clinical Trial Description

This is a single-center, randomized, double-blind, placebo-controlled clinical trial. OCT coronary images analyzed at an independent imaging core laboratory (Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China) by blinded expert readers. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04848857
Study type Interventional
Source Wuhan Union Hospital, China
Contact
Status Completed
Phase Phase 4
Start date May 3, 2021
Completion date October 5, 2023
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