The Role of Netrin -1 in Acute Coronary Syndrome

Acute Coronary Syndrome Clinical Trial

— ACS-NETRIN-1  

Official title:

The Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Presenting to the Emergency Department With Acute Coronary Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04027127
• Other study ID #: aksaray 2013-23
• Status: Completed
• Phase: N/A
• Start date: September 15, 2013
• Est. completion date: June 15, 2018

Study information

• Verified date: July 2019
• Source: Aksaray University Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher Netrin-1 levels.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 238
• Est. completion date: June 15, 2018
• Est. primary completion date: August 15, 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients over the age of 18

• diagnose ACS

• patients undergoing angiography

Exclusion Criteria:

• CVE history

• Neurological disease

• Pregnancy and Lactation

• Liver failure

• Diagnosed malignity

• Use of anticonvulsant and nephrotoxic medication

• Chronic kidney disease

• Not having angiography

• Developing acute renal failure after angiography

• Patients who rejected to participate were excluded.

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Syndrome

Intervention

Other:
• netrin-1 value on admission to hospital

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Aksaray University Training and Research Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	serum netrin-1 value	Netrin-1 in plasma was measured by enzyme-linked immunosorbent assay (ELISA) (Mybiosource MBS044526 ) All assays were performed in duplicate. Plasma Netrin-1 is expressed in picograms (pg) per mg.	30 minute