Phase III Acute Coronary Syndrome

Acute Coronary Syndrome Clinical Trial

— APPRAISE-2  

Official title:

Apixaban for Prevention of Acute Ischemic Events - 2 A Phase 3, Randomized, Double-Blind, Evaluation of the Safety and Efficacy of Apixaban In Subjects With a Recent Acute Coronary Syndrome

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00831441
• Other study ID #: CV185-068
• Secondary ID: EUDRACT# 2008-00
• Status: Terminated
• Phase: Phase 3
• First received: January 28, 2009
• Last updated: December 18, 2015
• Start date: March 2009
• Est. completion date: March 2011

Study information

• Verified date: December 2015
• Source: Bristol-Myers Squibb
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug Administration
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine if apixaban is superior to placebo for preventing cardiovascular death, non-fatal myocardial infarction, or ischemic stroke in subjects with a recent acute coronary syndrome

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 7484
• Est. completion date: March 2011
• Est. primary completion date: March 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Acute coronary syndrome (ACS)

• Clinically stable

• Receiving standard of care for ACS

Exclusion Criteria:

• Severe hypertension

• Active bleeding or high risk for major bleeding

• Hemoglobin < 9 g/dL

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Acute Coronary Syndrome
• Syndrome

Intervention

Drug:
• Apixaban
Tablets, Oral, 5 mg, twice daily, until study end
• Placebo
Tablets, Oral, 0 mg, twice daily, until study end

Locations

Country	Name	City	State
Argentina	Local Institution	Berazategui	Buenos Aires
Argentina	Local Institution	Buenos Aires
Argentina	Local Institution	Buenos Aires
Argentina	Local Institution	Buenos Aires
Argentina	Local Institution	Buenos Aires
Argentina	Local Institution	Buenos Aires
Argentina	Local Institution	Capital	Mendoza
Argentina	Local Institution	Capital Federal	Buenos Aires
Argentina	Local Institution	Cipolletti	Rio Negro
Argentina	Local Institution	Ciudad Autonoma Buenos Aires	Buenos Aires
Argentina	Local Institution	Ciudad Autonoma De Beunos Aire	Buenos Aires
Argentina	Local Institution	Cordoba
Argentina	Local Institution	Cordoba
Argentina	Local Institution	Cordoba
Argentina	Local Institution	Cordoba
Argentina	Local Institution	Coronel Suarez	Buenos Aires
Argentina	Local Institution	Corrientes
Argentina	Local Institution	Corrientes Capital	Corrientes
Argentina	Local Institution	Gaba	Buenos Aires
Argentina	Local Institution	Haedo	Buenos Aires
Argentina	Local Institution	Junin	Buenos Aires
Argentina	Local Institution	La Plata	Buenos Aires
Argentina	Local Institution	Lanus Oeste	Buenos Aires
Argentina	Local Institution	Moron	Buenos Aires
Argentina	Local Institution	Posadas	Misiones
Argentina	Local Institution	Quilmes	Buenos Aires
Argentina	Local Institution	Ramos Mejia	Buenos Aires
Argentina	Local Institution	Resistencia	Chaco
Argentina	Local Institution	Rosario	Santa Fe
Argentina	Local Institution	Rosario	Santa Fe
Argentina	Local Institution	Salta
Argentina	Local Institution	San Isidro	Buenos Aires
Argentina	Local Institution	San Luis
Argentina	Local Institution	San Martin	Buenos Aires
Argentina	Local Institution	San Miguel De Tucuman	Tucuman
Argentina	Local Institution	San Miguel De Tucuman	Tucuman
Argentina	Local Institution	San Salvador De Jujuy	Jujuy
Argentina	Local Institution	Santa Fe
Argentina	Local Institution	Santa Fe
Argentina	Local Institution	Villa Cabrera	Cordoba
Argentina	Local Institution	Villa Carlos Paz	Cordoba
Argentina	Local Institution	Villa Maria	Cordoba
Australia	Local Institution	Ashford	South Australia
Australia	Local Institution	Broken Hill	New South Wales
Australia	Local Institution	Bruce	Australian Capital Territory
Australia	Local Institution	Cairns	Queensland
Australia	Local Institution	Elizabeth Vale	South Australia
Australia	Local Institution	Fitzroy	Victoria
Australia	Local Institution	Geelong	Victoria
Australia	Local Institution	Herston	Queensland
Australia	Local Institution	Kogarah	New South Wales
Australia	Local Institution	Lismore	New South Wales
Australia	Local Institution	Milton	Queensland
Australia	Local Institution	Richmond	Victoria
Australia	Local Institution	Woodville	South Australia
Austria	Local Institution	Feldkirch
Austria	Local Institution	Graz
Austria	Local Institution	Linz
Austria	Local Institution	Oberpullendorf
Austria	Local Institution	Vienna
Austria	Local Institution	Vienna
Austria	Local Institution	Wien
Austria	Local Institution	Wien
Austria	Local Institution	Wien
Belgium	Local Institution	Aalst
Belgium	Local Institution	Anderlecht
Belgium	Local Institution	Antwerpen
Belgium	Local Institution	Bonheiden
Belgium	Local Institution	Brasschaat
Belgium	Local Institution	Brugge
Belgium	Local Institution	Gent
Belgium	Local Institution	Huy
Belgium	Local Institution	Ieper
Belgium	Local Institution	Mechelen
Belgium	Local Institution	Mol
Belgium	Local Institution	Yvoir
Brazil	Local Institution	Belem	Para
Brazil	Local Institution	Belo Horizonte	Minas Gerais
Brazil	Local Institution	Belo Horzonte	Minas Gerais
Brazil	Local Institution	Blumenau	Santa Catarina
Brazil	Local Institution	Brasilia	Distrito Federal
Brazil	Local Institution	Brasilia	Distrito Federal
Brazil	Local Institution	Brasilia	Distrito Federal
Brazil	Local Institution	Brasilia	Distrito Federal
Brazil	Local Institution	Campinas	Sao Paulo
Brazil	Local Institution	Curitiba	Parana
Brazil	Local Institution	Curitiba	Parana
Brazil	Local Institution	Curitiba	Parana
Brazil	Local Institution	Goiania	Goias
Brazil	Local Institution	Goiania	Goias
Brazil	Local Institution	Juiz De Fora	Mato Grosso
Brazil	Local Institution	Limeira	Sao Paulo
Brazil	Local Institution	Londrina	Parana
Brazil	Local Institution	Maceio	Alagoas
Brazil	Local Institution	Marilia	Sao Paulo
Brazil	Local Institution	Marilia	Sao Paulo
Brazil	Local Institution	Natal	Rio Grande Do Norte
Brazil	Local Institution	Passo Fundo	Rio Grande Do Sul
Brazil	Local Institution	Porto Alegre	Rio Grande Do Sul
Brazil	Local Institution	Porto Alegre	Rio Grande Do Sul
Brazil	Local Institution	Porto Alegre	Rio Grande Do Sul
Brazil	Local Institution	Porto Alegre	Rio Grande Do Sul
Brazil	Local Institution	Porto Alegre	Rio Grande Do Sul
Brazil	Local Institution	Porto Alegre	Rio Grande Do Sul
Brazil	Local Institution	Recife	Pernambuco
Brazil	Local Institution	Rio De Janeiro
Brazil	Local Institution	Rio De Janeiro
Brazil	Local Institution	Rio De Janeiro
Brazil	Local Institution	Rio Janeiro	Rio De Janeiro
Brazil	Local Institution	Salvador	Bahia
Brazil	Local Institution	Salvador	Bahia
Brazil	Local Institution	Salvador	Bahia
Brazil	Local Institution	Salvador	Bahia
Brazil	Local Institution	Santo Andre	Sao Paulo
Brazil	Local Institution	Santo Andre	Sao Paulo
Brazil	Local Institution	Sao Caetano Do Sul	Sao Paulo
Brazil	Local Institution	Sao Jose	Santa Catarina
Brazil	Local Institution	Sao Jose Do Rio Preto	Sao Paulo
Brazil	Local Institution	Sao Jose Do Rio Preto	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sao Paulo
Brazil	Local Institution	Sobral	Ceara
Brazil	Local Institution	Uberlandia	Minas Gerais
Brazil	Local Institution	Uberlandia	Minas Gerais
Bulgaria	Local Institution	Burgas
Bulgaria	Local Institution	Dimitrovgrad
Bulgaria	Local Institution	Pazardzhik
Bulgaria	Local Institution	Pleven
Bulgaria	Local Institution	Plovdiv
Bulgaria	Local Institution	Plovdiv
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Sofia
Bulgaria	Local Institution	Stara Zagora
Bulgaria	Local Institution	Varna
Canada	Local Institution	Cambridge	Ontario
Canada	Local Institution	Cambridge	Ontario
Canada	Local Institution	Chiccutimi	Quebec
Canada	Local Institution	Edmonton	Alberta
Canada	Local Institution	Edmonton	Alberta
Canada	Local Institution	Edmonton	Alberta
Canada	Local Institution	Grimsby	Ontario
Canada	Local Institution	Halifax	Nova Scotia
Canada	Local Institution	Kitchener	Ontario
Canada	Local Institution	Levis	Quebec
Canada	Local Institution	London	Ontario
Canada	Local Institution	Montreal	Quebec
Canada	Local Institution	New Westminster	British Columbia
Canada	Local Institution	Oshawa	Ontario
Canada	Local Institution	Oshawa	Ontario
Canada	Local Institution	Oshawa	Ontario
Canada	Local Institution	Parry Sound	Ontario
Canada	Local Institution	Penticton	British Columbia
Canada	Local Institution	Sarnia	Ontario
Canada	Local Institution	Scarborough	Ontario
Canada	Local Institution	Scarborough	Ontario
Canada	Local Institution	Sorel-Tracy	Quebec
Canada	Local Institution	St-Foy	Quebec
Canada	Local Institution	St-John	Newfoundland and Labrador
Canada	Local Institution	St. Charles Borromee	Quebec
Canada	Local Institution	St. Jerome	Quebec
Canada	Local Institution	Sudbury	Ontario
Canada	Local Institution	Sudbury	Ontario
Canada	Local Institution	Sudbury	Ontario
Canada	Local Institution	Sydney	Nova Scotia
Canada	Local Institution	Terrebonne	Quebec
Canada	Local Institution	Toronto	Ontario
Canada	Local Institution	Toronto	Ontario
Canada	Local Institution	Toronto	Ontario
Canada	Local Institution	Victoria	British Columbia
Canada	Local Institution	Windsor	Ontario
Canada	Local Institution	Winnipeg	Manitoba
Chile	Local Institution	Concepcion	Biobio
Chile	Local Institution	Osorno	Los Lagos
Chile	Local Institution	Puerto Montt
Chile	Local Institution	Punta Arenas	Magallanes Antartica
Chile	Local Institution	Santiago	Metropolitana
Chile	Local Institution	Santiago	Metropolitana
Chile	Local Institution	Santiago	Metropolitana
Chile	Local Institution	Santiago	Metropolitana
Chile	Local Institution	Santiago	Metropolitana
Chile	Local Institution	Talcahuano	Biobio
Chile	Local Institution	Temuco	Araucania
Chile	Local Institution	Vina Del Mar	Valparaiso
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Beijing
China	Local Institution	Beijing	Shanghai
China	Local Institution	Changchun	Jilin
China	Local Institution	Changchun	Jilin
China	Local Institution	Changsha	Hunan
China	Local Institution	Chengdu	Sichuan
China	Local Institution	Chongqing	Sichuan
China	Local Institution	Chongqing	Chongqing
China	Local Institution	Dalian	Liaoning
China	Local Institution	Guangzhou	Guangdong
China	Local Institution	Guangzhou	Guangdong
China	Local Institution	Guangzhou	Guangdong
China	Local Institution	Guangzhou	Guangdong
China	Local Institution	Hangzhou	Zhejiang
China	Local Institution	Hangzhou	Zhejiang
China	Local Institution	Harbin	Heilongjiang
China	Local Institution	Jinan	Shandong
China	Local Institution	Kunming	Yunnan
China	Local Institution	Lanzhou	Gansu
China	Local Institution	Nanchang	Jiangxi
China	Local Institution	Nanjing	Jiangsu
China	Local Institution	Nanjing	Jiangsu
China	Local Institution	Nanjing	Jiangsu
China	Local Institution	Nanning	Guangxi
China	Local Institution	Shanghai	Shanghai
China	Local Institution	Shanghai	Shanghai
China	Local Institution	Shanghai	Shanghai
China	Local Institution	Shenyang	Liaoning
China	Local Institution	Shenyang	Liaoning
China	Local Institution	Shenyang	Liaoning
China	Local Institution	Shijiazhuang	Hebei
China	Local Institution	Suzhou	Jiangsu
China	Local Institution	Suzhou	Jiangsu
China	Local Institution	Wuhan	Hubei
China	Local Institution	Xian
Colombia	Local Institution	Barranquilla
Colombia	Local Institution	Bogota
Colombia	Local Institution	Bogota	Cundinamaral
Colombia	Local Institution	Cali	Valle
Colombia	Local Institution	Cartagena	Bolivar
Colombia	Local Institution	Floridablanca
Colombia	Local Institution	Manizales
Colombia	Local Institution	Medelin
Colombia	Local Institution	Medellin
Czech Republic	Local Institution	Brno
Czech Republic	Local Institution	Hradec Kralove
Czech Republic	Local Institution	Liberec
Czech Republic	Local Institution	Novy Jicin
Czech Republic	Local Institution	Olomouc
Czech Republic	Local Institution	Ostrava
Czech Republic	Local Institution	Praha 10
Czech Republic	Local Institution	Rakovnik
Czech Republic	Local Institution	Usti Nad Orlici
Denmark	Local Institution	Arhus C
Denmark	Local Institution	Copenhagen
Denmark	Local Institution	Copenhagen
Denmark	Local Institution	Copenhagen
Denmark	Local Institution	Esbjerg
Denmark	Local Institution	Haderslev
Denmark	Local Institution	Hellerup
Denmark	Local Institution	Hillerod
Denmark	Local Institution	Hvidovre
Denmark	Local Institution	Naestved
Denmark	Local Institution	Silkeborg
Denmark	Local Institution	Slagelse
Finland	Local Institution	Espoo
Finland	Local Institution	Helsinki
Finland	Local Institution	Rovaniemi
Finland	Local Institution	Tampere
France	Local Institution	Albi Cedex 09
France	Local Institution	Amiens Cedex 1
France	Local Institution	Avignon
France	Local Institution	Cholet
France	Local Institution	Lagny Sur Marne
France	Local Institution	Langres Cedex
France	Local Institution	Montpellier
France	Local Institution	Paris Cedex 13
France	Local Institution	Pau Universite Cedex
France	Local Institution	Strasbourg Cedex
France	Local Institution	Toulouse Cedex 03
Germany	Local Institution	Bad Berka
Germany	Local Institution	Bad Nauheim
Germany	Local Institution	Berlin
Germany	Local Institution	Berlin
Germany	Local Institution	Berlin
Germany	Local Institution	Berlin
Germany	Local Institution	Bernau
Germany	Local Institution	Bonn
Germany	Local Institution	Bonn
Germany	Local Institution	Chemnitz
Germany	Local Institution	Coswig
Germany	Local Institution	Cottbus
Germany	Local Institution	Dachau
Germany	Local Institution	Essen
Germany	Local Institution	Flensburg
Germany	Local Institution	Halle/Saale
Germany	Local Institution	Hamburg
Germany	Local Institution	Hamburg
Germany	Local Institution	Hamburg
Germany	Local Institution	Hoyerswerda
Germany	Local Institution	Jena
Germany	Local Institution	Leverkusen
Germany	Local Institution	Limburg
Germany	Local Institution	Luebeck
Germany	Local Institution	Mainz
Germany	Local Institution	Muenster
Germany	Local Institution	Neuss
Germany	Local Institution	Paderborn
Germany	Local Institution	Pirna
Germany	Local Institution	Regensburg
Germany	Local Institution	Rostock
Germany	Local Institution	Wesel
Hungary	Local Institution	Baja
Hungary	Local Institution	Balatonfured
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budapest
Hungary	Local Institution	Budpest
Hungary	Local Institution	Cegled
Hungary	Local Institution	Debrecen
Hungary	Local Institution	Dunaujvaros
Hungary	Local Institution	Hodmezovasarhely
Hungary	Local Institution	Kecskemet
Hungary	Local Institution	Miskolc
Hungary	Local Institution	Miskolc
Hungary	Local Institution	Szekesfehervar
Hungary	Local Institution	Szekszard
Hungary	Local Institution	Szentes
Hungary	Local Institution	Szombathely
Hungary	Local Institution	Zalaegerszeg
India	Local Institution	Ahmedabad	Gujarat
India	Local Institution	Ahmedabad	Gujarat
India	Local Institution	Ahmedabad	Gujarat
India	Local Institution	Bangalore	Karnataka
India	Local Institution	Bangalore	Karnataka
India	Local Institution	Bangalore, Karnataka
India	Local Institution	Bikaner
India	Local Institution	Chennai	Tamilnadu
India	Local Institution	Coimbatore	Tamil Nadu
India	Local Institution	Gurgaon	Haryana
India	Local Institution	Hyderabad	Andhra Pradesh
India	Local Institution	Hyderabad	Andhra Pradesh
India	Local Institution	Indore	Madhya Pradesh
India	Local Institution	Jaipur	Rajasthan
India	Local Institution	Jaipur	Rajasthan
India	Local Institution	Jaipur	Rajasthan
India	Local Institution	Jalandhar	Punjab
India	Local Institution	Lucknow	Uttar Pradesh
India	Local Institution	Mangalore
India	Local Institution	Mumbai	Maharashtra
India	Local Institution	Mumbai	Maharashtra
India	Local Institution	Mysore	Karnataka
India	Local Institution	Nagpur	Maharashtra
India	Local Institution	Nagpur	Maharashtra
India	Local Institution	Nagpur	Maharashtra
India	Local Institution	New Delhi
India	Local Institution	New Delhi
India	Local Institution	Pune
India	Local Institution	Pune	Maharashtra
India	Local Institution	Pune	Maharastra
India	Local Institution	Shivamogga	Karnataka
India	Local Institution	Vadodara	Gujarat
India	Local Institution	Vijayawada	Andhra Pradesh
Israel	Local Institution	Afula
Israel	Local Institution	Ashkelon
Israel	Local Institution	Hadera
Israel	Local Institution	Haifa
Israel	Local Institution	Haifa
Israel	Local Institution	Haifa
Israel	Local Institution	Jerusalem
Israel	Local Institution	Jerusalem
Israel	Local Institution	Jerusalem
Israel	Local Institution	Jerusalem
Israel	Local Institution	Kfar-Saba
Israel	Local Institution	Nahariya
Israel	Local Institution	Nazareth
Israel	Local Institution	Nazareth
Israel	Local Institution	Petach Tikva
Israel	Local Institution	Rehovot
Israel	Local Institution	Safed
Israel	Local Institution	Tel Aviv
Israel	Local Institution	Tiberias
Italy	Local Institution	Ascoli Piceno
Italy	Local Institution	Bergamo
Italy	Local Institution	Chieti
Italy	Local Institution	Foggia
Italy	Local Institution	Gravedona (Co)
Italy	Local Institution	Grosseto
Italy	Local Institution	Massa
Italy	Local Institution	Milan
Italy	Local Institution	Milano
Italy	Local Institution	Naples
Italy	Local Institution	Novara
Italy	Local Institution	Pavia
Italy	Local Institution	Perugia
Italy	Local Institution	Roma
Italy	Local Institution	San Daniele Del Friuli (Udine)
Italy	Local Institution	Saronno (Va)
Italy	Local Institution	Verona
Japan	Local Institution	Ageo	Saitama
Japan	Local Institution	Beppu	Oita
Japan	Local Institution	Chiyoda-Ku	Tokyo
Japan	Local Institution	Chuo-Ku	Tokyo
Japan	Local Institution	Fukuoka
Japan	Local Institution	Gifu
Japan	Local Institution	Gifu-Shi	Gifu
Japan	Local Institution	Hachioji	Tokyo
Japan	Local Institution	Iwakuni	Yamaguchi
Japan	Local Institution	Kanazawa	Ishikawa
Japan	Local Institution	Kanoya	Kagoshima
Japan	Local Institution	Kasama	Ibaraki
Japan	Local Institution	Kasuga	Fukuoka
Japan	Local Institution	Kochi
Japan	Local Institution	Komatsushima	Tokushima
Japan	Local Institution	Koshigaya	Saitama
Japan	Local Institution	Kumamoto
Japan	Local Institution	Kumamoto
Japan	Local Institution	Kumamoto
Japan	Local Institution	Kumamoto
Japan	Local Institution	Kure	Hiroshima
Japan	Local Institution	Kurume	Fukuoka
Japan	Local Institution	Kyoto
Japan	Local Institution	Matsudo	Chiba
Japan	Local Institution	Meguro	Tokyo
Japan	Local Institution	Meguro-Ku	Tokyo
Japan	Local Institution	Nagoya	Aichi
Japan	Local Institution	Nagoya	Aichi
Japan	Local Institution	Nagoya	Aichi
Japan	Local Institution	Nagoya-Shi	Aichi
Japan	Local Institution	Obihiro	Hokkaido
Japan	Local Institution	Ogaki-Shi	Gifu
Japan	Local Institution	Oita
Japan	Local Institution	Osaka
Japan	Local Institution	Saga
Japan	Local Institution	Sakai	Osaka
Japan	Local Institution	Sapporo	Hokkaido
Japan	Local Institution	Seto-Shi	Aichi
Japan	Local Institution	Toda	Saitama
Japan	Local Institution	Tokyo
Japan	Local Institution	Tsuchiura-Shi	Ibaraki
Japan	Local Institution	Tsukuba	Ibaraki
Japan	Local Institution	Ube	Yamaguchi
Japan	Local Institution	Ueda	Nagano
Japan	Local Institution	Ureshino	Saga
Japan	Local Institution	Yokohama	Kanagawa
Japan	Local Institution	Yokohama	Kanagawa
Japan	Local Institution	Yokohama Sakae-Ku	Kanagawa
Japan	Local Institution	Yokosuka	Kanagawa
Korea, Republic of	Local Institution	Anyang	Gyeonggi-Do
Korea, Republic of	Local Institution	Daegu
Korea, Republic of	Local Institution	Goyang
Korea, Republic of	Local Institution	Guri-Si	Gyeonggi-Do
Korea, Republic of	Local Institution	Gwangju
Korea, Republic of	Local Institution	Incheon
Korea, Republic of	Local Institution	Incheon
Korea, Republic of	Local Institution	Jeonbuk
Korea, Republic of	Local Institution	Jinju	Gyeongsangam-Do
Korea, Republic of	Local Institution	Pusan
Korea, Republic of	Local Institution	Seoul
Korea, Republic of	Local Institution	Seoul
Korea, Republic of	Local Institution	Seoul
Korea, Republic of	Local Institution	Suwon
Korea, Republic of	Local Institution	Wonju	Gangwon-Do
Korea, Republic of	Local Institution	Yangsan	Gyeongangnam-Do
Mexico	Local Institution	Acapulco	Guerrero
Mexico	Local Institution	Acapulco	Guerrero
Mexico	Local Institution	Aguascalientes
Mexico	Local Institution	Aguascalientes
Mexico	Local Institution	Cabo San Lucas	Baja Californa Sur
Mexico	Local Institution	Chihuahua
Mexico	Local Institution	Culiacan	Sinaloa
Mexico	Local Institution	Durango
Mexico	Local Institution	Guadalajara	Jalisco
Mexico	Local Institution	Guadalajara	Jalisco
Mexico	Local Institution	Guadalajara	Jalisco
Mexico	Local Institution	Metepec	Estado De Mexico
Mexico	Local Institution	Monclova	Coahuila
Mexico	Local Institution	Monterrey	Nuevo Leon
Mexico	Local Institution	Monterrey	Nuevo Leon
Mexico	Local Institution	Monterrey	Nuevo Leon
Mexico	Local Institution	Monterrey	Nuevo Leon
Mexico	Local Institution	Monterrey	Nuevo Leon
Mexico	Local Institution	Pachuca	Hidalgo
Mexico	Local Institution	Queretaro
Mexico	Local Institution	San Luis Potosi
Mexico	Local Institution	Tijuana	Baja California
Mexico	Local Institution	Tlalnepantla	Estado De Mexico
Mexico	Local Institution	Veracruz
Mexico	Local Institution	Xalapa	Veracruz
Mexico	Local Institution	Zapopan	Jalisco
Netherlands	Local Institution	Alkmaar
Netherlands	Local Institution	Almere
Netherlands	Local Institution	Amsterdam
Netherlands	Local Institution	Beverwijk
Netherlands	Local Institution	Boxmeer
Netherlands	Local Institution	Den Haag
Netherlands	Local Institution	Dirksland
Netherlands	Local Institution	Ede
Netherlands	Local Institution	Goes
Netherlands	Local Institution	Gouda
Netherlands	Local Institution	Heerlen
Netherlands	Local Institution	Hilversum
Netherlands	Local Institution	Maastrict
Netherlands	Local Institution	Meppel
Netherlands	Local Institution	Purmerend
Netherlands	Local Institution	Sneek
Netherlands	Local Institution	Veldhoven
Netherlands	Local Institution	Weert
Netherlands	Local Institution	Zwolle
New Zealand	Local Institution	Auckland
New Zealand	Local Institution	Auckland
New Zealand	Local Institution	Christchurch
New Zealand	Local Institution	Hastings
New Zealand	Local Institution	Nelson
New Zealand	Local Institution	Palmerston North
Norway	Local Institution	Bergen
Norway	Local Institution	Bodo
Norway	Local Institution	Drammen
Norway	Local Institution	Hamar
Norway	Local Institution	Kongsvinger
Norway	Local Institution	Kristiansund
Norway	Local Institution	Lillehammer
Norway	Local Institution	Oslo
Norway	Local Institution	Oslo
Norway	Local Institution	Oslo
Norway	Local Institution	Stavanger
Norway	Local Institution	Tynset
Peru	Local Institution	Bellavista	Callao
Peru	Local Institution	Callao
Peru	Local Institution	Chiclayo	Lambayeque
Peru	Local Institution	Cusco
Peru	Local Institution	Ica
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Peru	Local Institution	Lima
Poland	Local Institution	Bialystok
Poland	Local Institution	Bydgoszcz
Poland	Local Institution	Bytom
Poland	Local Institution	Czestochowa
Poland	Local Institution	Elblag
Poland	Local Institution	Gdynia
Poland	Local Institution	Grodzisk Mazowiecki
Poland	Local Institution	Inowroclaw
Poland	Local Institution	Kielce
Poland	Local Institution	Koscierzyna
Poland	Local Institution	Krakow
Poland	Local Institution	Krakow
Poland	Local Institution	Lodz
Poland	Local Institution	Lodz
Poland	Local Institution	Lublin
Poland	Local Institution	Lublin
Poland	Local Institution	Opole
Poland	Local Institution	Ostrowiec Swietokrzyski
Poland	Local Institution	Plock
Poland	Local Institution	Poznan
Poland	Local Institution	Radom
Poland	Local Institution	Rzeszow
Poland	Local Institution	Slupsk
Poland	Local Institution	Szczecin
Poland	Local Institution	Tarnow
Poland	Local Institution	Torun
Poland	Local Institution	Warsaw
Poland	Local Institution	Warszawa
Poland	Local Institution	Warszawa
Poland	Local Institution	Warszawa
Poland	Local Institution	Wegrow	Mazowiekie
Poland	Local Institution	Wloclawek
Poland	Local Institution	Zabrze
Poland	Local Institution	Zielona Gora
Puerto Rico	Local Institution	Cidra
Puerto Rico	Local Institution	San Juan
Romania	Local Institution	Arad
Romania	Local Institution	Baia Mare
Romania	Local Institution	Braila
Romania	Local Institution	Bucharest
Romania	Local Institution	Bucharest
Romania	Local Institution	Bucharest
Romania	Local Institution	Bucharest
Romania	Local Institution	Craiova
Romania	Local Institution	Oradea
Romania	Local Institution	Pitesti
Romania	Local Institution	Sibiu
Romania	Local Institution	Targu Mures
Romania	Local Institution	Timisoara
Russian Federation	Local Institution	Barnaul
Russian Federation	Local Institution	Chelyabinsk
Russian Federation	Local Institution	Ekaterinburg
Russian Federation	Local Institution	Ekaterinburg
Russian Federation	Local Institution	Kaluga
Russian Federation	Local Institution	Kazan
Russian Federation	Local Institution	Kemerovo
Russian Federation	Local Institution	Krasnoyarsk
Russian Federation	Local Institution	Krasnoyarsk
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow
Russian Federation	Local Institution	Moscow Reg. Zhekeznodorozhniy
Russian Federation	Local Institution	Nizhni Novgorod
Russian Federation	Local Institution	Nizhny Novgorod
Russian Federation	Local Institution	Nizhny Novgorod
Russian Federation	Local Institution	Novosibirsk
Russian Federation	Local Institution	Novosibirsk
Russian Federation	Local Institution	Novosibirsk
Russian Federation	Local Institution	Novosibirsk
Russian Federation	Local Institution	Odintsovo
Russian Federation	Local Institution	Penza
Russian Federation	Local Institution	Perm
Russian Federation	Local Institution	Rostov-On-Don
Russian Federation	Local Institution	Ryazan
Russian Federation	Local Institution	Saint Petersburg
Russian Federation	Local Institution	Saint Petersburg
Russian Federation	Local Institution	Saint Petersburg
Russian Federation	Local Institution	Saint Petersburg
Russian Federation	Local Institution	Saint Petersburg
Russian Federation	Local Institution	Saint-Petersburg
Russian Federation	Local Institution	Saint-Petersburg
Russian Federation	Local Institution	Saint-Petersburg
Russian Federation	Local Institution	Saint-Petersburg
Russian Federation	Local Institution	Saint-Petersburg
Russian Federation	Local Institution	Saratov
Russian Federation	Local Institution	Saratov
Russian Federation	Local Institution	St. Petersburg
Russian Federation	Local Institution	St. Petersburg
Russian Federation	Local Institution	St. Petersburg
Russian Federation	Local Institution	Tomsk
Russian Federation	Local Institution	Tver
Russian Federation	Local Institution	Tyumen
Russian Federation	Local Institution	Vasilievsky Island
Russian Federation	Local Institution	Voronezh
Russian Federation	Local Institution	Yaroslavl
Russian Federation	Local Institution	Yaroslavl
Russian Federation	Local Institution	Yaroslavl
Russian Federation	Local Institution	Yaroslavl
Russian Federation	Local Institution	Zhukovskiy
Singapore	Local Institution	Singapore
Singapore	Local Institution	Singapore
Slovakia	Local Institution	Banska Bystrica
Slovakia	Local Institution	Bratislava
Slovakia	Local Institution	Kosice
Slovakia	Local Institution	Kosice
Slovakia	Local Institution	Kosice
Slovakia	Local Institution	Kralovsky Chlmec
Slovakia	Local Institution	Liptovsky Hradok
Slovakia	Local Institution	Lucenec
Slovakia	Local Institution	Martin
Slovakia	Local Institution	Nitra
South Africa	Local Institution	Bellville	Western Cape
South Africa	Local Institution	Bloemfontein	Free State
South Africa	Local Institution	Bloemfontein	Free State
South Africa	Local Institution	Centurion	Gauteng
South Africa	Local Institution	Durban	Kwa Zulu Natal
South Africa	Local Institution	Durban	Kwa Zulu Natal
South Africa	Local Institution	Durban	Kwa Zulu Natal
South Africa	Local Institution	Johannesburg
South Africa	Local Institution	Kuils River	Western Cape
South Africa	Local Institution	Pinelands	Western Cape
South Africa	Local Institution	Port Elizabeth	Eastern Cape
South Africa	Local Institution	Port Elizabeth	Eastern Cape
South Africa	Local Institution	Somerset West	Western Cape
South Africa	Local Institution	Umhlanga	Kwa Zulu Natal
South Africa	Local Institution	Wapadrand - Pretoria	Gauteng
South Africa	Local Institution	Worcester	Western Cape
Spain	Local Institution	Almeria
Spain	Local Institution	Barcelona
Spain	Local Institution	Barcelona
Spain	Local Institution	Caceres
Spain	Local Institution	El Ejido
Spain	Local Institution	Figueres	Gerona
Spain	Local Institution	Granada
Spain	Local Institution	Lleida
Spain	Local Institution	Lugo
Spain	Local Institution	Madrid
Spain	Local Institution	Madrid
Spain	Local Institution	Madrid
Spain	Local Institution	Madrid
Spain	Local Institution	Madrid
Spain	Local Institution	Madrid
Spain	Local Institution	Malaga
Spain	Local Institution	Oviedo	Asturas
Spain	Local Institution	San Sebastian De Los Reyes	Madrid
Spain	Local Institution	Santiago De Compostela
Spain	Local Institution	Sevilla
Spain	Local Institution	Tarragona
Spain	Local Institution	Torrevieja
Spain	Local Institution	Valencia
Spain	Local Institution	Valladolid
Spain	Local Institution	Villajoyosa	Alicante
Spain	Local Institution	Zaragoza
Sweden	Local Institution	Eskilstuna
Sweden	Local Institution	Halmstad
Sweden	Local Institution	Helsingborg
Sweden	Local Institution	Karlskoga
Sweden	Local Institution	Karlstad
Sweden	Local Institution	Koping
Sweden	Local Institution	Lidkoping
Sweden	Local Institution	Molndal
Sweden	Local Institution	Skovde
Sweden	Local Institution	Stockholm
Sweden	Local Institution	Stockholm
Sweden	Local Institution	Uppsala
Sweden	Local Institution	Vaxjo
Switzerland	Local Institution	Geneve
Switzerland	Local Institution	Lugano	Ticino
Switzerland	Local Institution	St Gallen
Switzerland	Local Institution	Zurich
Switzerland	Local Institution	Zurich
Turkey	Local Institution	Ankara
Turkey	Local Institution	Besevler	Ankara
Turkey	Local Institution	Bornova	Izmir
Turkey	Local Institution	Diyarbakir
Turkey	Local Institution	Isanbul	Haseki
Turkey	Local Institution	Isparta
Turkey	Local Institution	Kirikkale
Turkey	Local Institution	Konya
Ukraine	Local Institution	Chernivtsy
Ukraine	Local Institution	Dnipropetrovsk
Ukraine	Local Institution	Dnipropetrovsk
Ukraine	Local Institution	Donetsk
Ukraine	Local Institution	Donetsk
Ukraine	Local Institution	Donetsk
Ukraine	Local Institution	Ivano-Frankivsk
Ukraine	Local Institution	Kharkiv
Ukraine	Local Institution	Kharkiv
Ukraine	Local Institution	Kharkiv
Ukraine	Local Institution	Kharkiv
Ukraine	Local Institution	Kharkiv
Ukraine	Local Institution	Kyiv
Ukraine	Local Institution	Kyiv
Ukraine	Local Institution	Kyiv
Ukraine	Local Institution	Kyiv
Ukraine	Local Institution	Lugansk
Ukraine	Local Institution	Lutsk
Ukraine	Local Institution	Lviv
Ukraine	Local Institution	Lviv
Ukraine	Local Institution	Mykolayiv
Ukraine	Local Institution	Odessa
Ukraine	Local Institution	Odessa
Ukraine	Local Institution	Simferopol
Ukraine	Local Institution	Vinnitsa
Ukraine	Local Institution	Zhaporizhzhya
United Kingdom	Local Institution	Ayr	Ayrshire
United Kingdom	Local Institution	Basildon	Essex
United Kingdom	Local Institution	Belfast	Antrim
United Kingdom	Local Institution	Belfast	Armagh
United Kingdom	Local Institution	Blackpool	Lancashire
United Kingdom	Local Institution	Cambridge	Cambridgeshire
United Kingdom	Local Institution	Chelmsford	Essex
United Kingdom	Local Institution	Chesterfield	Derbyshire
United Kingdom	Local Institution	Cottingham	East Yorkshire
United Kingdom	Local Institution	Doncaster	South Yorkshire
United Kingdom	Local Institution	Dumfries	Dumfriesshire
United Kingdom	Local Institution	Harrow	Middlesex
United Kingdom	Local Institution	Kilmarnock	Ayrshire
United Kingdom	Local Institution	New Castle Upon Tyne	Tyne And Wear
United Kingdom	Local Institution	Portadown	Armagh
United Kingdom	Local Institution	Romford	Essex
United Kingdom	Local Institution	Scunthorpe	Lincolnshire
United Kingdom	Local Institution	Tunbridge Wells	Kent
United Kingdom	Local Institution	Worksop	Nottinghamshire
United States	Otfried N. Niedermaier, Md	Akron	Ohio
United States	Phase Care, Llc	Alameda	California
United States	Alexandria Cardiology Clinic	Alexandria	Louisiana
United States	Clinical Research Network	Alexandria	Louisiana
United States	Endeavor Medical Research, Plc	Alpena	Michigan
United States	Orlando Heart Specialists	Altamonte Springs	Florida
United States	Blair Medical Associates, Inc.	Altoona	Pennsylvania
United States	Amarillo Heart Clinical Research Institute Inc.	Amarillo	Texas
United States	Mcfarland Clinic Pc	Ames	Iowa
United States	Cardiology Consultants Of Orange County	Anaheim	California
United States	Anmed Health	Anderson	South Carolina
United States	Carl Wilson Sofley, Jr., Md	Anderson	South Carolina
United States	Local Institution	Annapolis	Maryland
United States	Asheville Cardiology Associates	Asheville	North Carolina
United States	Kentucky Heart & Vascular Physicians	Ashland	Kentucky
United States	Cardiovascular Physicians Of North Atlanta	Atlanta	Georgia
United States	Palm Beach Heart Institute, Llc	Atlantis	Florida
United States	Medical College Of Georgia	Augusta	Georgia
United States	Beaver Medical Group	Banning	California
United States	City Cardiology Associates	Barberton	Ohio
United States	Blue Stem Cardiology	Bartlesville	Oklahoma
United States	Lowcountry Medical Group	Beaufort	South Carolina
United States	St. Charles Health System, Inc.	Bend	Oregon
United States	St. Lukes Cardiology Associates	Bethlehem	Pennsylvania
United States	Uab Medical Center	Birmingham	Alabama
United States	University Of Alabama At Birmingham	Birmingham	Alabama
United States	Rocky Mountain Cardiology	Boulder	Colorado
United States	Local Institution	Brick	New Jersey
United States	New York Methodist Hospital	Brooklyn	New York
United States	Buffalo General Hospital	Buffalo	New York
United States	Memorial Hospital Of Carbondale	Carbondale	Illinois
United States	The University Of North Carolina At Chapel Hill	Chapel Hill	North Carolina
United States	The Chattanooga Heart Institute	Chattanooga	Tennessee
United States	Bermisa Family Practice & Research Center	Chesapeake	Virginia
United States	Northwestern University	Chicago	Illinois
United States	Rush University Medical Center	Chicago	Illinois
United States	University Of Chicago Hospitals	Chicago	Illinois
United States	Local Institution	Chula Vista	California
United States	Cincinnati Veterans Affairs Medical Center	Cincinnati	Ohio
United States	Ronald L. Walsh, Do	Clearwater	Florida
United States	The Heart And Vascular Institute Of Florida	Clearwater	Florida
United States	Columbia Cardiology	Columbia	South Carolina
United States	Missouri Cardiovascular Specialists	Columbia	Missouri
United States	Columbus Cardiology Associates Pc	Columbus	Georgia
United States	Georgia Heart Specialists	Covington	Georgia
United States	Cardiovascular Research Institute Of Dallas	Dallas	Texas
United States	Dallas Va Medical Center	Dallas	Texas
United States	Heart Consultants Of North Texas	Dallas	Texas
United States	Zakhary, Bosh	Danville	Virginia
United States	Cardiovascular Specialist Of South Florida	Davie	Florida
United States	Atlanta Institute For Medical Research, Inc	Decatur	Georgia
United States	Henry Ford Hospital	Detroit	Michigan
United States	Local Institution	Detroit	Michigan
United States	In-Quest Medical Research, Llc	Duluth	Georgia
United States	Alta Pharmaceutical Research Center, Inc.	Dunwoody	Georgia
United States	Duke University Medical Center	Durham	North Carolina
United States	Central Jersey Medical Research Center	Elizabeth	New Jersey
United States	Elkhart Clinic, Llc	Elkhart	Indiana
United States	North Georgia Medical Research	Ellijay	Georgia
United States	Consultants In Cardiovascular Diseases, Inc.	Erie	Pennsylvania
United States	Hamot Medical Center	Erie	Pennsylvania
United States	Escondido Cardiology Associates, Inc.	Escondido	California
United States	Fairfield Cardiac Cath Lab, Llc	Fairfield	Ohio
United States	Local Institution	Fargo	North Dakota
United States	Sparks Regional Medical Center	Fort Smith	Arkansas
United States	T&R Clinic	Fort Worth	Texas
United States	Texas Health Research & Education Institute	Fort Worth	Texas
United States	David E. Perloff, Md	Ft. Lauderdale	Florida
United States	Northeast Georgia Heart Cntr, Pc	Gainesville	Georgia
United States	Genoa Medical Center	Genoa	Ohio
United States	The Stern Cardiovascular Center, Pa	Germantown	Tennessee
United States	Genesys Regional Medical Center	Grand Blanc	Michigan
United States	East Carolina Heart Institute At East Carolina University	Greenville	North Carolina
United States	Clinical Investigation Specialists, Inc	Gurnee	Illinois
United States	Hamilton Cardiology Associates	Hamilton	New Jersey
United States	St Margaret Mercy Healthcare Centers	Hammond	Indiana
United States	Hartford Hospital	Hartford	Connecticut
United States	Local Institution	Hazard	Kentucky
United States	William D. Bowden, D.O.	Healdsburg	California
United States	Heart Care Associates P.C.	Hopewell	Virginia
United States	Centex Research, Pineloch Medical Clinic	Houston	Texas
United States	Heart Care Center	Houston	Texas
United States	Med Tech, Inc.	Houston	Texas
United States	Methodist Debakey Heart & Vascular Center	Houston	Texas
United States	Northwest Houston Cardiology, Pa	Houston	Texas
United States	California Heart Specialists, Inc.	Huntington Beach	California
United States	Heart Center Research, Llc	Huntsville	Alabama
United States	Krannertt Institute Of Cardiology	Indianapolis	Indiana
United States	R. L.Roudebush Va Medical Center	Indianapolis	Indiana
United States	The Care Group, Llc	Indianapolis	Indiana
United States	Nature Coast Clinical Research	Inverness	Florida
United States	Local Institution	Jackson	Mississippi
United States	Research Associates Of Jackson	Jackson	Tennessee
United States	University Of Mississippi Medical Center	Jackson	Mississippi
United States	East Coast Institute For Research	Jacksonville	Florida
United States	Jacksonville Center For Clinical Research	Jacksonville	Florida
United States	Jacksonville Heart Center, Pa	Jacksonville	Florida
United States	Gateway Cardiology. P.C	Jerseyville	Illinois
United States	Mountain State Health Alliance	Johnson City	Tennessee
United States	Richard M. Kastelic M.D. & Associates, P.C.	Johnstown	Pennsylvania
United States	Nea Baptist Clinic	Jonesboro	Arkansas
United States	Knoxville Heart Group	Knoxville	Tennessee
United States	Caring Clinical Research Corporation	Laguna Hills	California
United States	The Cardio Vascular Center P.A.	Lake Mary	Florida
United States	Eisenstein, Isaac	Lakewood	California
United States	The Heart Group	Lancaster	Pennsylvania
United States	Thoracic And Cardiovascular Healthcare Foundation	Lansing	Michigan
United States	Utah Cardiology P.C	Layton	Utah
United States	Bryanlgh Heart Institute	Lincoln	Nebraska
United States	Local Institution	Linden	New Jersey
United States	South Denver Cardiology Associates Pc	Littleton	Colorado
United States	Midwest Heart Foundation	Lombard	Illinois
United States	Arvind J. Mehta, Md	Long Beach	California
United States	Local Institution	Los Alamitos	California
United States	Preciado Cardiology Incorporated	Los Angeles	California
United States	Cardiovascular Associates, Psc	Louisville	Kentucky
United States	Texas Cardiac Center	Lubbock	Texas
United States	The Cardiology Group Centra.	Lynchburg	Virginia
United States	Mercer University School Of Medicine	Macon	Georgia
United States	Dean And St. Mary'S Outpatient Center	Madison	Wisconsin
United States	Virginia Cardiolovascular Associates	Manassas	Virginia
United States	Well Star Cardiovascular Medicine, Pc	Marietta	Georgia
United States	Dr. Michael Sacher	Massapequa	New York
United States	Alpha Medical Research, Llc	Melbourne	Florida
United States	Melbourne Internal Medicine Associates (Mima)	Melbourne	Florida
United States	Advanced Pharma Clinical Research	Miami	Florida
United States	Glenn J. Barquet, Md	Miami	Florida
United States	Miami Cardiology Clinical Research, L.L.C.	Miami	Florida
United States	Mount Sinai Medical Center	Miami Beach	Florida
United States	Middletown Cardiovascular Associates	Middletown	Ohio
United States	Local Institution	Midlothian	Virginia
United States	Wheaton Franciscan Healthcare St. Joseph	Milwaukee	Wisconsin
United States	Hennepin County Medical Center	Minneapolis	Minnesota
United States	University Of Minnesota, Medical School	Minneapolis	Minnesota
United States	Va Medical Center	Minneapolis	Minnesota
United States	Local Institution	Moline	Illinois
United States	Local Institution	Mt. Pleasant	Michigan
United States	Medical Consultants, Pc	Muncie	Indiana
United States	Access Clinical Trials	Nashville	Tennessee
United States	Tulane University Hospital And Clinic	New Orleans	Louisiana
United States	Alfieri Cardiology	Newark	Delaware
United States	Sendara Cardiovasular Research Institute	Norfolk	Virginia
United States	Illinois Heart & Lung Research	Normal	Illinois
United States	Parkway Cardiology Associates, Pc	Oak Ridge	Tennessee
United States	East Bay Physicians Medical Group	Oakland	California
United States	Mediquest Research Group Inc.	Ocala	Florida
United States	Ocala Research Institute, Inc	Ocala	Florida
United States	Cor Clinical Research, Llc	Oklahoma City	Oklahoma
United States	Oklahoma Cardiovascular Associates	Oklahoma City	Oklahoma
United States	University Of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma
United States	Alegent Health Clinic Heart & Vascular Specialists	Omaha	Nebraska
United States	Heart Consultants	Omaha	Nebraska
United States	St. Joseph Heritage Medical Group	Orange	California
United States	Florida Heart Group	Orlando	Florida
United States	Orlando Heart Center	Orlando	Florida
United States	Midwest Cardiology Associates , P.C.	Overland Park	Kansas
United States	Research Integrity, Llc	Owensboro	Kentucky
United States	Palm Beach Gardens Research Center Llc	Palm Beach Gardens	Florida
United States	Local Institution	Pembroke Pines	Florida
United States	Cardiology Consultants	Pensacola	Florida
United States	Heartcare Midwest	Peoria	Illinois
United States	Drexel University College Of Medicine	Philadelphia	Pennsylvania
United States	Penn Presbyterian Medical Center	Philadelphia	Pennsylvania
United States	Pennsylvania Cardiology Associates	Philadelphia	Pennsylvania
United States	North Phoenix Heart Center	Phoenix	Arizona
United States	Advent Clinical Research Centers, Inc.	Pinellas Park	Florida
United States	Va Pittsburgh Healthcare System	Pittsburgh	Pennsylvania
United States	Cardio-Pulmonary Associates	Plantation	Florida
United States	Avivo Clin Clinical Services	Port Orange	Florida
United States	Portland Preventive Cardiology, L.L.C.	Portland	Oregon
United States	Pottstown Medical Specialists, Inc	Pottstown	Pennsylvania
United States	Hudson Valley Heart Center	Poughkeepsie	New York
United States	The Miriam Hospital	Providence	Rhode Island
United States	Wake Med Heart Center	Raleigh	North Carolina
United States	Cardiology Assoicates, Pc/Black Hills Clinical Research Ctr	Rapid City	South Dakota
United States	A.R.I. Clinical Trials, Inc.	Redondo Beach	California
United States	Virgina Commonwealth Universitymedical Center	Richmond	Virginia
United States	The Valley Hospital	Ridgewood	New Jersey
United States	Southern Heart Research Institute, Llc	Riverdale	Georgia
United States	Covenant Medical Center, Inc	Saginaw	Michigan
United States	Delmarva Heart Research Foundation	Salisbury	Maryland
United States	Peninsula Cardiology Associates, P.A.	Salisbury	Maryland
United States	Central Cardiovascular Institute Of San Antonio	San Antonio	Texas
United States	Jose A. Perez, M.D.	San Antonio	Texas
United States	S.A.M. Clinical Research Center	San Antonio	Texas
United States	Coastal Multi-Specialty Research	Santa Ana	California
United States	Radiant Research, Inc	Santa Rosa	California
United States	Heartcare Research	Sarasota	Florida
United States	Local Institution	Scranton	Pennsylvania
United States	Buxmont Cardiology Associates, Pc	Sellersville	Pennsylvania
United States	Louisiana State University Health Sciences Center-Shreveport	Shreveport	Louisiana
United States	Overton Brooks V.A.M.C.	Shreveport	Louisiana
United States	North Central Heart Institute	Sioux Falls	South Dakota
United States	Louisiana Heart Center	Slidell	Louisiana
United States	Central New Jersey Cardiology	South Plainfield	New Jersey
United States	Inland Cardiology Associates	Spokane	Washington
United States	St. Augustine Cardiology Associates	St. Augustine	Florida
United States	St Cloud Hospital	St. Cloud	Minnesota
United States	Great Lakes Heart & Vascular Institute, Pc	St. Joseph	Michigan
United States	Gateway Cardiology, P.C.	St. Louis	Missouri
United States	Washington University School Of Medicine	St. Louis	Missouri
United States	Sugarland Cardiology Associates	Sugarland	Texas
United States	Franciscan Research Center	Tacoma	Washington
United States	Dr Kiran C Patel Research Institute At Pepin Heart Hospital	Tampa	Florida
United States	Scott&White Memorial Hospital	Temple	Texas
United States	Toledo Cardiology Consultants	Toledo	Ohio
United States	Northwest Heart Center	Tomball	Texas
* Note: There are 1014 locations in all - only the first 1000 are shown.

Sponsors (3)

Lead Sponsor	Collaborator
Bristol-Myers Squibb	Duke Clinical Research Institute, Pfizer

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Austria,  Belgium,  Brazil,  Bulgaria,  Canada,  Chile,  China,  Colombia,  Czech Republic,  Denmark,  Finland,  France,  Germany,  Hungary,  India,  Israel,  Italy,  Japan,  Korea, Republic of,  Mexico,  Netherlands,  New Zealand,  Norway,  Peru,  Poland,  Puerto Rico,  Romania,  Russian Federation,  Singapore,  Slovakia,  South Africa,  Spain,  Sweden,  Switzerland,  Turkey,  Ukraine,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Event Rate of Cardiovascular Death, Myocardial Infarction, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants	Event rate was percent of participants with an event of cardiovascular (CV) death, myocardial infarction (MI), or ischemic stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Study was terminated early and last patient, last visit was in Year 2. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes (eg, cardiogenic shock, heart failure, arrhythmia/sudden death, cardiac rupture, ischemic stroke, pulmonary embolism, venous/arterial thrombotic events) and other sudden deaths for which an alternative cause was not identified. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).	Randomization (Day 1) to first event (CV death, MI, ischemic stroke), up to March 2011, approximately 2 years	No
Primary	Event Rate of Confirmed Major Bleeding Using Thrombolysis in Myocardial Infarction (TIMI) Criteria During the Treatment Period - Treated Participants	TIMI Major Bleed Criteria: Fatal bleeding, intracranial hemorrhage, and clinically overt bleeding with a hemoglobin (Hgb) drop of = 5 grams per deciliter (g/dL), or =15% absolute decrease in hematocrit. To account for transfusions, Hgb measurements were adjusted for transfusions. A transfusion of 1 unit of blood was assumed to result in an increase by 1 g/dL in Hgb or 3% in hematocrit. Event rate was percent of participants with an event of Major Bleed as per TIMI (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Treatment Period=events with onset from first dose to last dose plus 2 days.	From first dose to first occurrence of event (TIMI major bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years	Yes
Secondary	Event Rate of Unstable Angina (UA) During the Intended Treatment Period - Randomized Participants	Unstable Angina (UA) defined as worsening or recurrent severe or repetitive angina symptoms at rest lasting at least 10 minutes with at least 2 of the following: New and dynamic electrocardiogram (ECG) changes; angina symptoms leading to inpatient hospitalization; angina symptoms leading to an unplanned or urgent cardiac catheterization, with or without revascularization, that showed evidence of hemodynamically and clinically significant stenosis. Event rate was percent of participants with an event of unstable angina (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: the period that started on the day of randomization and ended at the efficacy cut-off date (cut-off date: the date all sites were informed that study drug should be discontinued for all participants, 18 November 2010).	Randomization (Day 1) to first event of UA, up to March 2011, approximately 2 years	No
Secondary	Event Rate of Stroke During the Intended Treatment Period - Randomized Participants	Event rate was percent of participants with an event of stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause (ie, brain tumor). All strokes were classified as hemorrhagic (documentation on imaging (eg computed tomography scan or magnetic resonance imaging) of hemorrhage in the cerebral parenchyma, or a subdural or subarachnoid hemorrhage), non-hemorrhagic/ischemic stroke, ischemic stroke with hemorrhagic conversion, or type unknown. Intended Treatment Period: the period that started on the day of randomization (Day 1) and ended at the efficacy cut-off date (notification of study termination).	Randomization (Day 1) to first event (stroke), up to March 2011, approximately 2 years	No
Secondary	Event Rate of Myocardial Infarction (MI) During the Intended Treatment Period - Randomized Participants	MI took into account whether the participant had a recent percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) surgery. Selected key criteria: Elevation of cardiac biomarkers (eg, Creatine Kinase MB fraction (CKMB), Troponin T, Troponin I) above the upper reference limit (URL) plus ischemic symptoms, ECG changes, or imaging evidence of new loss of viable myocardium or new regional wall motion abnormality; Death of CV etiology with new ST-segment elevation or left bundle branch block (LBBB) or fresh intracoronary thrombus by angiography or at autopsy occurring before biomarkers could be obtained or before their appearance in the blood; Following a PCI, elevation of cardiac biomarkers more than 3*URL; Following CABG surgery, elevation of cardiac biomarkers more than 5*URL; New, significant (=0.04 s) Q waves in =2 contiguous leads; Pathologic findings of acute MI. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice.	Randomization (Day 1) to first event (MI), up to March 2011, approximately 2 years	No
Secondary	Event Rate of Stent Thrombosis During the Intended Treatment Period - Randomized Participants	Stent thrombosis: Definite stent thrombosis considered to have occurred by either angiographic or pathological confirmation; Probable stent thrombosis considered to have occurred in the following cases: any unexplained death within the first 30 days after stent implantation; irrespective of the time after the procedure, any MI that was related to documented acute ischemia in the territory of the implanted stent without angiographic confirmation of stent thrombosis and in the absence of any other obvious cause; Possible stent thrombosis considered to have occurred with any unexplained death from 30 days after intracoronary stenting until end of study (in Year 2). Event rate was percent of participants with an event of stent thrombosis (number with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off notice of study termination.	Randomization (Day 1) to first event (stent thrombosis), up to March 2011, approximately 2 years	No
Secondary	Event Rate of Composite of Cardiovascular Death, Myocardial Infarction, Unstable Angina, or Ischemic Stroke During the Intended Treatment Period - Randomized Participants	Event rate was percent of participants with an event of CV death, MI, unstable angina (UA), or ischemic stroke (number of participants with event/number randomized) per 100-pt years. Only events confirmed by the adjudication committee were included in the analyses. Each type of event was counted once per participant, but participants could have been counted in multiple categories. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).	Randomization (Day 1) to first event (CV death, MI, UA, Ischemic Stroke, up to March 2011, approximately 2 years	No
Secondary	Event Rate of Composite of Cardiovascular Death, Fatal Bleed, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants	Event rate was percent of participants with an event of CV death, fatal bleed, MI, or stroke (number of participants with event/number randomized) per 100 patient (100-pt) years. Only events confirmed by the adjudication committee were included in the analyses. CV death included deaths due to CV causes; Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause; Fatal bleeding defined as bleeding that Adjudication Committee determined was the primary cause of death or contributed directly to death; MI took into account whether the participant had a recent PCI or CABG surgery. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).	Randomization (Day 1) to first event (CV death, Fatal Bleed, MI, or stroke), up to March 2011, approximately 2 years	No
Secondary	Event Rate of Composite of All-Cause Death, Myocardial Infarction, or Stroke During the Intended Treatment Period - Randomized Participants	Cause of death was determined by the principal condition that caused the death, not the immediate mode of death.; CV death: included deaths due to CV causes. Non-CV death: included non-CV deaths caused primarily by a malignancy, infection, bleeding, trauma, non-CV system organ failure, or non-CV surgery. Unknown: included deaths that were not attributable to one of the above categories of CV death or to a non-CV cause. MI accounted whether the participant had a recent PCI or CABG surgery. Diagnosis of stroke required a new, non-traumatic, focal neurological deficit of sudden onset, lasting at least 24 hours that was not due to a readily identifiable non-vascular cause. Only events confirmed by the adjudication committee were included in analyses. Intended Treatment Period: Day of randomization (Day 1) to efficacy cut-off date (notification of study termination).	Randomization (Day 1) to first event (All Cause Death, MI, or Stroke), up to March 2011, approximately 2 years	No
Secondary	Event Rate of Confirmed Major Bleeding Using International Society on Thrombosis and Hemostasis (ISTH) Criteria During the Treatment Period - Treated Participants	ISTH Criteria: Acute clinically overt bleeding defined as new onset, visible bleeding or signs or symptoms suggestive of bleeding confirmed by imaging techniques, which can detect the presence of blood (eg, ultrasound, CT, MRI). Major bleeding: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed red blood cells (RBCs); Bleeding that occurs in at least one of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; thus, a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. Bleeding events were adjudicated by the Adjudication Committee. Event rate was percent of participants with an event (number with event/number randomized) per 100-pt years. Treatment Period=events with onset from first dose to last dose plus 2 days.	From first dose to first occurrence of event (ISTH major bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years	Yes
Secondary	Event Rate of Confirmed Major Bleeding or Clinically Relevant Non-Major Bleeding (CRNM) Using ISTH Criteria During the Treatment Period - Treated Participants	ISTH Major bleed: acute clinically overt bleeding accompanied by one or more of the following: A decrease in Hgb of 2 g/dL or more over 24 hours; A transfusion of 2 or more units of packed RBCs; Bleeding that occurs in at least one of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye), pericardial, intra-articular, intramuscular with compartment syndrome, retroperitoneal; Bleeding that was fatal. CRNM: acute clinically overt bleeding that did not satisfy additional criteria required for the bleeding event to be defined as a major bleeding event and meets at least one of the following: Hospital admission for bleeding; Physician guided medical or surgical treatment for bleeding; Change in anti-thrombotic treatment (anticoagulant or antiplatelet) therapy. Bleeding events were adjudicated by the Adjudication Committee. Treatment Period=events with onset from first dose to last dose plus 2 days.	From first dose to first occurrence of event (ISTH major or CRNM bleed) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years	Yes
Secondary	Event Rate of All Bleeding Reported by the Investigator During the Treatment Period - Treated Participants	Bleeding events were adjudicated by the Adjudication Committee and classified according to Thrombolysis in Myocardial Infarction (TIMI) major, minor, minimal, and International Society on Thrombosis and Hemostasis (ISTH) major and clinically relevant non-major bleeding (CRNM) criteria. The adjudicated results based on TIMI and ISTH classifications, and programmatically identified events (not adjudicated) according to Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) classification were used in the analyses of bleeding endpoints. GUSTO Bleed Criteria included Severe or life-threatening: Intracranial hemorrhage, or bleeding that causes hemodynamic compromise requiring intervention; Moderate: Bleeding that requires a blood transfusion, but does not result in hemodynamic compromise; Mild: Bleeding that does not meet criteria for either severe or moderate bleeding. Treatment Period=events with onset from first dose to last dose plus 2 days.	From first dose to first occurrence of event (Bleeding) during Treatment Period (first dose to last dose + 2 days), up to March 2011, approximately 2 years	Yes

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