Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to determine the best dose of nebulized arformoterol, a quick onset but long acting beta agonist, for use in treating acute bronchospasm in asthmatics presenting to the the Emergency Department. Also this study will evaluate the side effect and safety profile of arformoterol when used in this situation.


Clinical Trial Description

Acute bronchospasm associated with exacerbations of asthma is a common problem. Currently the mainstay of treatment is inhalation albuterol, either levalbuterol or racemic mixture, in repetitive fashion depending on the resolution of the airways obstruction. Formoterol is a long-acting (>12 hours) selective beta2-agonist that has a very rapid onset of bronchodilatation (<3 minutes and thus similar to that produced by albuterol). Patients with acute bronchospasm could benefit from the prn use of formoterol as they would receive acute relief of their symptoms and this would last for a prolonged time period. Additionally formoterol has been reported to be 28-109 times as potent as albuterol and safe at doses of 54ug in healthy subjects and asthmatics. Racemic formoterol structurally has 2 chiral centers and thus is composed of 4 enantiomers. The RR form (or arformoterol) is the active bronchodilator and it is not clear what the physiologic actions of the other 3 enantiomers are. This study is the first to evaluate nebulized arformoterol solution for therapy of acute asthmatics presenting to the Emergency Department. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT00819637
Study type Interventional
Source Henry Ford Health System
Contact
Status Terminated
Phase Phase 4
Start date January 2009
Completion date November 2009

See also
  Status Clinical Trial Phase
Completed NCT01429415 - Magnesium Nebulization Utilization in Management of Pediatric Asthma Phase 2
Completed NCT01196377 - Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study N/A
Completed NCT00733317 - Budesonide for Emergency Treatment of Acute Wheezing in Children Phase 4
Completed NCT00733473 - Nebulized Budesonide for Children Who Are Hospitalized for Acute Wheezing Phase 4
Completed NCT01695031 - Feasibility of an ED Initiated Online Asthma Management Program for Urban Teens N/A
Recruiting NCT04016220 - Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Phase 1
Active, not recruiting NCT06005337 - Supporting Parents to Choose Wisely N/A
Completed NCT01079000 - Emergency Department (ED)-Directed Interventions to Improve Asthma Outcomes N/A
Completed NCT00922350 - Heliox and Posture in Patients With Asthma N/A
Completed NCT03698630 - Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children Phase 4
Completed NCT01868113 - Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial Phase 3
Completed NCT01016444 - Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms
Completed NCT00393367 - Budesonide Inhalation Suspension for Acute Asthma in Children Phase 4
Completed NCT03369119 - Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children Phase 4
Completed NCT01304901 - Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children. Phase 4
Completed NCT01403467 - Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation Phase 4