Clinical Trials Logo

Clinical Trial Summary

Leukotriene receptor antagonists (LTRAs) are well established in the management of outpatient asthma. Montelukast is a potent, specific, orally active, cysteinyl leukotriene receptor antagonist with a rapid onset of action.However, there is very little information as to their role in acute asthma exacerbations.

The purpose of this study is to determine if adding oral montelukast to the maximal standard treatment in children hospitalized for acute asthma has any additive benefit.


Clinical Trial Description

Background: Montelukast is a potent, specific, orally active, cysteinyl leukotriene receptor antagonist with a rapid onset of action.

Objective: To evaluate the effect of the addition of a single dose of oral montelukast to standard therapy in acute asthma. Design: Double-blind, randomised, controlled, parallel group trial. Setting: Pediatric service of Education and training Hospital Patients: Children with the ages of 6-60 months who were hospitalized for acute asthma Intervention: Children received montelukast 4 mg or placebo orally in addition to the standard therapy. Clinical asthma score was recorded before administering study medication and thereafter, 4 hourly until discharge. Main outcome measure: The primary outcome was discharge rates. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03369119
Study type Interventional
Source Kecioren Education and Training Hospital
Contact
Status Completed
Phase Phase 4
Start date August 2011
Completion date December 2012

See also
  Status Clinical Trial Phase
Completed NCT01429415 - Magnesium Nebulization Utilization in Management of Pediatric Asthma Phase 2
Completed NCT01196377 - Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study N/A
Completed NCT00733317 - Budesonide for Emergency Treatment of Acute Wheezing in Children Phase 4
Completed NCT00733473 - Nebulized Budesonide for Children Who Are Hospitalized for Acute Wheezing Phase 4
Completed NCT01695031 - Feasibility of an ED Initiated Online Asthma Management Program for Urban Teens N/A
Recruiting NCT04016220 - Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Phase 1
Active, not recruiting NCT06005337 - Supporting Parents to Choose Wisely N/A
Completed NCT01079000 - Emergency Department (ED)-Directed Interventions to Improve Asthma Outcomes N/A
Completed NCT00922350 - Heliox and Posture in Patients With Asthma N/A
Completed NCT03698630 - Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children Phase 4
Terminated NCT00819637 - A Pilot Study to Determine the Most Effective Dose of Arformoterol for Treating Acute Asthmatic Patients Phase 4
Completed NCT01868113 - Inhaled Corticosteroids in U-5 Children With Acute Respiratory Infection in Uganda: A Randomised Trial Phase 3
Completed NCT01016444 - Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms
Completed NCT00393367 - Budesonide Inhalation Suspension for Acute Asthma in Children Phase 4
Completed NCT01304901 - Effect of Addition of Single Dose of Oral Montelukast to Standard Treatment in Acute Asthma in Preschool Children. Phase 4
Completed NCT01403467 - Impact of Continuous Positive Airway Pressure on the Treatment of Acute Asthma Exacerbation Phase 4