Snow Properties and Its Modeling for Studying Gas Exchange Under the Simulated Avalanche Snow

Accident Caused by Snow Avalanche Clinical Trial

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Official title:

Snow Properties and Its Modeling for Studying Gas Exchange Under the Simulated Avalanche Snow

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03413878
• Other study ID #: VentRes-2018-01-KR
• Status: Active, not recruiting
• Phase: N/A
• Start date: January 29, 2018
• Est. completion date: May 20, 2022

Study information

• Verified date: February 2021
• Source: Czech Technical University in Prague
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the study is to investigate respiratory parameters of a person in the simulated avalanche snow and consequent use of the measured data for development of a mathematical-physical model of breathing during increasing hypercapnia in the avalanche.

Description:

The study is a part of a university research project aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. Presence of an air pocket and its size play an important role in survival of victims buried in the avalanche snow. Even small air pockets facilitate breathing, yet they do not provide a significant amount of fresh air for breathing. The investigators hypothesize that the size of the air pocket significantly affects the airflow resistance and work of breathing. The aim of the study is to investigate the effect of the air pocket volume on gas exchange and work of breathing in subjects breathing into the simulated avalanche snow.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 45
• Est. completion date: May 20, 2022
• Est. primary completion date: May 20, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• healthy and fit volunteers, classified as The American Society of Anesthesiologists class I
• without a smoking history

Exclusion Criteria:

• Tiffeneau Index less than 0.70
• any cardiovascular or respiratory condition

Related Conditions & MeSH terms

• Accident Caused by Snow Avalanche

Intervention

Other:
• Breathing in the simulated avalanche snow
Breathing in the simulated wet or dry avalanche snow with a small or large air pocket

Locations

Country	Name	City	State
Czechia	Czech Technical University, Faculty of Biomedical Engineering	Kladno
Czechia	Charles University, Czech Republic	Prague

Sponsors (3)

Lead Sponsor	Collaborator
Czech Technical University in Prague	Charles University, Czech Republic, Ministry of Defence and Armed Forces of the Czech Republic

Country where clinical trial is conducted

Czechia, 

References & Publications (5)

Bellani G, Patroniti N, Weismann D, Galbiati L, Curto F, Foti G, Pesenti A. Measurement of pressure-time product during spontaneous assisted breathing by rapid interrupter technique. Anesthesiology. 2007 Mar;106(3):484-90. — View Citation

Brugger H, Sumann G, Meister R, Adler-Kastner L, Mair P, Gunga HC, Schobersberger W, Falk M. Hypoxia and hypercapnia during respiration into an artificial air pocket in snow: implications for avalanche survival. Resuscitation. 2003 Jul;58(1):81-8. — View Citation

Grissom CK, Radwin MI, Harmston CH, Hirshberg EL, Crowley TJ. Respiration during snow burial using an artificial air pocket. JAMA. 2000 May 3;283(17):2266-71. — View Citation

Roubík K, Sieger L, Sykora K. Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study. PLoS One. 2015 Dec 14;10(12):e0144332. doi: 10.1371/journal.pone.0144332. eCollection 2015. — View Citation

Strapazzon G, Paal P, Schweizer J, Falk M, Reuter B, Schenk K, Gatterer H, Grasegger K, Dal Cappello T, Malacrida S, Riess L, Brugger H. Effects of snow properties on humans breathing into an artificial air pocket - an experimental field study. Sci Rep. 2017 Dec 15;7(1):17675. doi: 10.1038/s41598-017-17960-4. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The length of breathing	Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.	Continuously within 30 minute interval from the beginning of the breathing experiment

External Links

•   Work of Breathing into Snow in the Presence versus Absence of an Artificial Air Pocket Affects Hypoxia and Hypercapnia of a Victim Covered with Avalanche Snow: A Randomized Double Blind Crossover Study