Abscess Clinical Trial
Official title:
Prospective Randomized Double Blind, Placebo-Controlled Trial of Septra for Uncomplicated Skin Abscesses in Patients at Risk for Community Acquired Methicillin-Resistant Staphylococcus Aureus Infection on 30 Day Recurrence Rates.
Patients will be enrolled in a multi-center study (Wilford Hall Medical Center and Brooke Army Medical Center) to prospectively evaluate outcome after treatment for an uncomplicated skin abscess.
All patients will receive incision and drainage and wound cultures. Patients will then be randomized to 1) septa double strength two pills orally twice a day x 7 days or 2)placebo. Patients will then return to the emergency room on days 3 and 7 for wound repacking and evaluation. The primary outcome recurrence rates within 30 days of treatment. Patients who are not improving at the following visit will then be treated with additional antibiotics if needed. Data will be analyzed both by initial randomization and intention to treat. ;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03127371 -
Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess
|
N/A | |
| Completed |
NCT02240498 -
Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities
|
Phase 1 | |
| Completed |
NCT00746109 -
Study of Wound Packing After Superficial Skin Abscess Drainage
|
Phase 4 | |
| Completed |
NCT00352612 -
Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections
|
Phase 4 | |
| Completed |
NCT00402727 -
Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection
|
Phase 3 | |
| Completed |
NCT00137085 -
Ketamine Versus Fentanyl as an Adjunct to Propofol-Assisted Emergency Department Procedural Sedation
|
N/A | |
| Completed |
NCT02714023 -
Water And Saline Head-to-head In The Blinded Evaluation Study Trial
|
N/A | |
| Completed |
NCT02264392 -
US Guided Versus BlindI&D for Treatment of Soft Tissue Abscesses in the ED
|
N/A | |
| Active, not recruiting |
NCT05226260 -
Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care
|
N/A | |
| Withdrawn |
NCT04241471 -
Incision and Loop Drainage Utilizing a Novel Technique for Management of Cutaneous Abscess in an Adult Population
|
N/A | |
| Recruiting |
NCT06284473 -
Ketamine as a Supplement to Local Anesthesia for Minor Procedures
|
Phase 4 | |
| Completed |
NCT01235546 -
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
|
N/A | |
| Withdrawn |
NCT00900510 -
Antibiotic Therapy After Incision and Drainage for Abscess
|
N/A | |
| Not yet recruiting |
NCT03917134 -
Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess After Laparoscopic Hysterectomy
|
N/A | |
| Withdrawn |
NCT02703233 -
Effectiveness of Nitrous Oxide in the ED
|
Phase 4 | |
| Completed |
NCT01557426 -
Soft Tissue Ultrasound of Infections
|
Phase 1 | |
| Completed |
NCT01339091 -
Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
|
Phase 3 | |
| Terminated |
NCT00867789 -
Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department
|
N/A | |
| Completed |
NCT01784458 -
Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
|
N/A | |
| Completed |
NCT00984022 -
Aquacel Versus Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage
|
Phase 2 |