Clinical Trials Logo
  1. Home
  2. Abscess
  3. NCT00417768

Safety and Effectiveness of tPA in Intra-abdominal Abscesses

Abscess Clinical Trial

Official title:
Safety and Effectiveness of Local Instillation of tPA in the Management of Complex Intra-abdominal Fluid Collections: a Randomized, Double Blinded Controlled Clinical Trial

Clinical Trial Summary

To determine if instillation of tissue plasminogen activator into a percutaneously drained intra-abdominal abscess cavity results in faster resolution of the abscess compared to normal standard of care.

Clinical Trial Description

On day 0 Subjects will have Tissue Plasminogen Activator injected into a drainage tube and allowed to dwell in the intra-abdominal abscess for one hour before allowing it to drain by gravity. This will be repeated on day 1 and 2. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00417768
Study type Interventional
Source University Health Network, Toronto
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date July 2005
Completion date November 2013
View Details
See also
  Status Clinical Trial Phase
Terminated NCT03127371 - Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess N/A
Completed NCT02240498 - Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities Phase 1
Completed NCT00746109 - Study of Wound Packing After Superficial Skin Abscess Drainage Phase 4
Completed NCT00402727 - Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection Phase 3
Completed NCT00352612 - Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections Phase 4
Completed NCT00137085 - Ketamine Versus Fentanyl as an Adjunct to Propofol-Assisted Emergency Department Procedural Sedation N/A
Completed NCT02714023 - Water And Saline Head-to-head In The Blinded Evaluation Study Trial N/A
Completed NCT02264392 - US Guided Versus BlindI&D for Treatment of Soft Tissue Abscesses in the ED N/A
Active, not recruiting NCT05226260 - Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care N/A
Withdrawn NCT04241471 - Incision and Loop Drainage Utilizing a Novel Technique for Management of Cutaneous Abscess in an Adult Population N/A
Recruiting NCT06284473 - Ketamine as a Supplement to Local Anesthesia for Minor Procedures Phase 4
Not yet recruiting NCT06052956 - Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses Phase 2
Completed NCT01235546 - Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection N/A
Withdrawn NCT00900510 - Antibiotic Therapy After Incision and Drainage for Abscess N/A
Not yet recruiting NCT03917134 - Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess After Laparoscopic Hysterectomy N/A
Withdrawn NCT02703233 - Effectiveness of Nitrous Oxide in the ED Phase 4
Completed NCT01557426 - Soft Tissue Ultrasound of Infections Phase 1
Completed NCT01339091 - Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections Phase 3
Terminated NCT00867789 - Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department N/A
Completed NCT01784458 - Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis N/A