Abdominal Aortic Aneurysm Clinical Trial
Official title:
Advanced MRI in AAA
This study aims to determine whether advanced MRI sequences can provide robust and clinically
relevant information about abdominal aortic aneurysms (AAAs). The MRI sequences will study
outcomes related to blood flow inside AAA, microvasculature of the AAA vessel wall and
intraluminal thrombus inside AAA.
Robustness of these MRI sequences will be determined with testing of feasibility and
reproducibility. Clinical relevance will be assessed by studying the association between the
primary outcomes and disease severity. Disease severity will be expressed by AAA diameter.
It is our hypothesis that these parameters are significantly related to disease severity and
may therefore be future markers of disease progression.
This prospective study evaluates the feasibility, reproducibility and clinical relevance of
MRI sequences in adults with an abdominal aortic aneurysm (AAA).
The MRI sequences and their primary outcomes are:
- Four-dimensional (4D) flow MRI and wall shear stress (WSS)
- Dynamic Contrast-Enhanced (DCE) MRI and kinetic transport constant (Ktrans)
- T1 and T2 mapping (T1 and T2 relaxation times)
Feasibility is tested by the production of high-quality images that enable calculation of the
primary outcomes. Reproducibility is tested by calculating interscan, intra- and
interobserver variability. Clinical relevance is tested by assessing the association between
primary outcomes and disease severity which is expressed by AAA diameter
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