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Zoonotic Disease clinical trials

View clinical trials related to Zoonotic Disease.

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NCT ID: NCT04717622 Recruiting - Brucellosis Clinical Trials

Investigation of Fever Suspected as a Zoonosis Using Advanced Diagnostic Technologies

Start date: May 23, 2021
Phase:
Study type: Observational

Zoonosis including brucellosis and rickettsial infections are a major contributor to infectious morbidity in southern Israel. The Bedouins, a nomadic tribal population residing in the Negev area are notably exposed to domesticated animals including livestock, camels and companion animals, and their living conditions, especially with respect to poor sanitation in different Bedouin communities also expose them to rodents and disease vectors such as insects and arthropods. In this study, we aim to identify Bedouin patients arriving at the Soroka University Medical Center, a tertiary hospital un the Negev, with undifferentiated fever, suspected as a zoonosis. We intend to use molecular methods to better diagnose the infectious agent using whole blood and serum samples, and when available other tissues or body fluid, and use next generation sequencing technology to deeply examine bacterial features such as virulence factors, and host pathogen interactions.

NCT ID: NCT04495569 Completed - Vaccine Reaction Clinical Trials

A Bridging Study of the SYN023 on Healthy Adult Subjects

Start date: February 26, 2019
Phase: Phase 1/Phase 2
Study type: Interventional

The Phase I bridging clinical trial is to evaluate on the safety, pharmacokinetics (PK), pharmacodynamics (PD) and ADA of a single intramuscular injection of recombinant anti-rabies human monoclonal antibody injection (SYN023) alone or combined with rabies vaccine in healthy subjects. The study primary purpose was to compare the pharmacokinetics (PK) between U.S and China subjects, therefore to lay a foundation for the follow-up clinical trials. The secondary purpose was to evaluate the PK, PD, Safety and ADA of SYN023 in Chinese Healthy subjects and compare with that of U.S. subjects.

NCT ID: NCT04012164 Completed - Zoonotic Disease Clinical Trials

Viral and Microbial Circulation Between Humans, Domesticated and Wild Animals Along an Ecotone, Democratic Republic of Congo

MICROTONE
Start date: March 15, 2019
Phase: N/A
Study type: Interventional

This study will evaluate the overlap between the intestinal microbiome and virome of wild and domesticated animals and human beings living in close proximity in three sites along an ecotone (ecological gradient) in the Democratic Republic of Congo.