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Safety and Immunogenicity of a Candidate ZIKV Vaccine (ZIKA001)

Zika Clinical Trial

Official title:
A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Zika Virus (ZIKV) Vaccine ChAdOx1 Zika in Healthy Adult Volunteers.

Clinical Trial Summary

This is a FIH, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx1 Zika vaccine in healthy volunteers administered intramuscularly.

Clinical Trial Description

Volunteers will be recruited and vaccinated at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford. There will be 3 study groups and a total of 24 volunteers will be enrolled. Groups 1-3 will receive ChAdOx1 Zika alone. Staggered enrolment will apply for the first three volunteers within each group. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04015648
Study type Interventional
Source University of Oxford
Contact
Status Completed
Phase Phase 1
Start date October 21, 2019
Completion date March 10, 2022
View Details
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