Ocular Manifestations in Rheumatic Diseases

Status Completed

Clinical Trial Summary

This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.

Clinical Trial Description

For the purposes of determining the prevalence of ocular complications in inflammatory rheumatic diseases, the following search terms were used: conjunctivitis, keratoconjunctivitis sicca, xerophthalmia, uveitis, eye hemorrhage, optic neuritis, papilledema, orbital disease, retinal artery/vein occlusion, macular edema, retinitis, chorioretinitis, scleritis, iridocyclitis, choroid hemorrhage, blindness and amaurosis fugax. These terms were searched in the context of a corresponding inflammatory disease on Medline, Cochrane and Web of Science from their inception (1966, 1991 and 1990 respectively) until the point of study completion. Studies were included if they provided numerical data of the prevalence or incidence of ocular manifestations in an inflammatory rheumatic disease. Studies were excluded if they were review articles, case reports where all patients experienced the same ocular comorbidity, if different comorbidities were not grouped independently, and if the study reported on fewer than 20 patients. When the same study cohort was used in more than one analysis, the most recent or largest sample-size study was included. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist was used to assess the quality of cohort, case-control, and cross-sectional studies. ;

Study Design

Related Conditions & MeSH terms

Amaurosis Fugax
Blindness
Chorioretinitis
Choroid Hemorrhage
Collagen Diseases
Conjunctivitis
Dry Eye Syndromes
Eye Hemorrhage
Hemorrhage
Iridocyclitis
Keratoconjunctivitis
Keratoconjunctivitis Sicca
Macular Edema
Neuritis
Optic Neuritis
Orbital Diseases
Papilledema
Retinal Artery Occlusion
Retinal Vein Occlusion
Retinitis
Rheumatic Diseases
Scleritis
Uveitis
Xerophthalmia

Clinical Trial Details

NCT number	NCT03753893
Study type	Observational
Source	Lawson Health Research Institute
Contact
Status	Completed
Phase
Start date	May 1, 2013
Completion date	November 1, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04292912` - A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2798745 in Participants With Diabetic Macular Edema	Phase 1
Recruiting	`NCT05976139` - Micropulsed Laser in Patients With Macular Oedema in Retinal Dystrophies	N/A
Completed	`NCT03660345` - PPV With Internal Limiting Membrane Peeling for Treatment-Naïve DME	Phase 3
Completed	`NCT03660371` - ILM Peeling in PDR Patients Undergoing PPV for VH	N/A
Completed	`NCT01660802` - Safety and Efficacy Study of Dexamethasone in the Treatment of Patients With Macular Edema Following Retinal Vein Occlusion (RVO)	Phase 3
Completed	`NCT01908816` - An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.	Phase 3
Completed	`NCT04592419` - A Study to Evaluate the Efficacy, Durability, and Safety of KSI-301 Compared to Aflibercept in Patients With Macular Edema Due to Retinal Vein Occlusion (RVO)	Phase 3
Completed	`NCT02867735` - A Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Activity of Intravitreal LKA651 in Patients With Macular Edema	Phase 1
Completed	`NCT02623673` - Simultaneous Therapy With Intravitreal Dexamethasone Implant and Bevacizumab for the Treatment of Macular Edema	N/A
Terminated	`NCT01946399` - Ozurdex Implant for Macular Edema After Treatment Failure With Anti-VEGF	N/A
Completed	`NCT01428388` - Bevacizumab Versus Ranibizumab in Treatment of Macular Edema From Vein Occlusion	N/A
Completed	`NCT01231633` - Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)	N/A
Recruiting	`NCT01023113` - To Compare Visual Field Impairment in Conventional Double Frequency Nd: YAG Panretinal Photocoagulation With PASCAL Panretinal Photocoagulation	N/A
Terminated	`NCT00969293` - Study to Assess the Safety and Tolerability of a Single Administration of FOV2302 (Ecallantide) in Patients With Macular Edema Associated With Central Retinal Vein Occlusion	Phase 1
Terminated	`NCT00918554` - Efficacy Study of Methotrexate to Treat Sarcoid-associated Uveitis	Phase 4
Completed	`NCT00970957` - Safety and Effectiveness of Bevacizumab Intravitreal Injections in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion	Phase 3
Completed	`NCT00476593` - Retinal OCT and (mfERG) Related to Age, Sex, and the Use of Anti-inflammatory Medications	N/A
Completed	`NCT00668239` - Diffuse Diabetic Maculopathy With Intravitreal Triamcinolone or Laser	N/A
Completed	`NCT00411970` - 20- Versus 23- Gauge System for Pars Plana Vitrectomy	Phase 4
Terminated	`NCT01939691` - Macular Edema Nepafenac vs. Difluprednate Uveitis Trial	Phase 4