Influence of Mango Intake of Skin Health in Postmenopausal Women

Wrinkle Clinical Trial

— MSS  

Official title:

Influence of Mango Intake on Skin Health in Postmenopausal Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03590756
• Other study ID #: 1185928
• Status: Completed
• Phase: N/A
• Start date: July 17, 2018
• Est. completion date: May 31, 2019

Study information

• Verified date: October 2019
• Source: University of California, Davis
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos. Participants will be instructed to consume the specific portion 4 times a week, for a total duration of 16 weeks.

Description:

Mangoes are rich in carotenoids, flavonoids, vitamins and other active phytochemicals such as resistant starches. Although a role of mangoes in skin health has long been advocated in traditional medicine, little scientific research has been conducted.

We hypothesize that 85g (0.5 cups) of mango intake for 16 weeks will have minimal impact on skin health, while 250g (1.5 cups) of mango intake will produce significant benefits.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: May 31, 2019
• Est. primary completion date: May 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 50 Years to 70 Years

Eligibility

Inclusion Criteria:

• Postmenopausal

• Fitzpatrick skin type I and II

• BMI 18.5 - 35.0 kg/m2

• Normal blood levels in the comprehensive metabolic panel, or values slightly out of range as approved by the study physician

Exclusion Criteria:

• Allergic to mangoes

• Fruit consumption of 2 or more cups per day

• Vegetable consumption of 3 or more cups per day for females

• Fruit juice consumption of more than 1 cup per day

• Self-reported malabsorption

• Currently taking regular prescription drugs i.e. statins, thyroid, anti-inflammatory drugs

• Had any medical or cosmetic procedures such as laser resurfacing or plastic surgery to the face within the last 6 months, including botulinum toxin, dermal fillers, collagen or other similar cosmetic procedure

• Autoimmune photosensitive condition or known genetic condition with a deficiency in collagen production (such as Ehler-Danlos)

• Smoking (current smoker, smoked within the past year, former smokers with greater than a 20 pack-year history of smoking within the past 20 years.

• Indications of substance or alcohol abuse

• Unwillingness to discontinue high antioxidant supplements during washout and interventions

Related Conditions & MeSH terms

• Skin Red
• Wrinkle

Intervention

Other:
• 16 weeks mango intake
Participants will be provided fresh frozen Ataulfo mangoes.

Locations

Country	Name	City	State
United States	Ragle Human Nutrition Research Center	Davis	California

Sponsors (2)

Lead Sponsor	Collaborator
University of California, Davis	National Mango Board

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Skin Wrinkle Depth and Redness	Using a skin camera from BrighTex Bio-Photonics to measure change in skin wrinkle depth and redness within a period of 16 weeks.	0, 8, and 16 week
Primary	Skin carotenoid	Using a skin photometer (Veggie Meter) to measure change in skin carotenoid within a period of 16 weeks.	0, 4, 8, 12, and 16 weeks
Secondary	Sebum	Sebum will be collected with sebutapes from the face and stored for possible further analysis.	0, 8, 16, weeks
Secondary	Plasma carotenoid	Plasma samples will be collected and stored at -80C for possible further analysis	0, 8, 16 weeks.