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Wounds and Injury clinical trials

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NCT ID: NCT06374225 Recruiting - Critical Illness Clinical Trials

Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention

SAVE-O2 AI
Start date: April 29, 2024
Phase: N/A
Study type: Interventional

This study is a multicenter randomized controlled trial to determine the effectiveness of a closed loop/autonomous oxygen titration system (O2matic PRO100) to maintain normoxemia (goal range SpO2 90-96%, target 93%) during the first 72 hours of acute injury or illness, compared to standard provider-driven methods (manual titration with SpO2 target of 90-96%).

NCT ID: NCT05411484 Recruiting - Wounds and Injury Clinical Trials

Investigation of Laser Assisted Drug Delivery of NanoDOX®

Start date: November 29, 2023
Phase: Phase 2
Study type: Interventional

This is a self-controlled single-site study of 10 healthy subjects receiving an ablative fractional CO2 laser procedure followed by topical application of NanoDOX® Hydrogel (1% doxycycline). The study includes skin biopsies to evaluate the effects of NanoDOX® Doxycycline Monohydrate Gel on wound healing after the ablative laser procedure. Study subjects will be asked to do two visits of approximately 4 hours over two weeks.

NCT ID: NCT04753723 Completed - Burn Wound Clinical Trials

The Use of a Platform Wound Device for Reducing Infection

Start date: February 8, 2021
Phase: Phase 4
Study type: Interventional

This study will evaluate the safety and efficacy of a novel Platform Wound Device (PWD) in its delivery of a local antibiotic, 0.1% Gentamycin cream, to prevent or treat infection in torso and extremity wounds. The hypothesis is that the PWD will be a safe and effective method to provide topical antibiotics to a torso or extremity wound, non-inferior to the current standard of care. This treatment will reduce or rapidly eradicate infection.

NCT ID: NCT04534972 Active, not recruiting - Critical Illness Clinical Trials

Strategy to Avoid Excessive Oxygen in Major Burn Patients

SAVE-O2
Start date: April 15, 2021
Phase: Phase 3
Study type: Interventional

The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in major burn patients. Investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy.

NCT ID: NCT04534959 Active, not recruiting - Critical Illness Clinical Trials

Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients

SAVE-O2
Start date: October 15, 2020
Phase: Phase 3
Study type: Interventional

The objective is to determine the effectiveness of a multimodal educational intervention to reduce supplemental oxygen use in critically injured patients. Investigators will also evaluate the safety and clinical effectiveness of the more targeted use of oxygen therapy.

NCT ID: NCT04460872 Recruiting - Clinical trials for Spinal Cord Injuries

Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

Start date: January 31, 2021
Phase: Phase 2
Study type: Interventional

This pilot study will determine the feasibility of implementing a combinatory rehabilitation strategy involving testosterone replacement therapy (TRT) with locomotor training (LT; walking on a treadmill with assistance and overground walking) in men with testosterone deficiency and walking dysfunction after incomplete or complete spinal cord injury. The investigators hypothesize that LT+TRT treatment will improve muscle size and bone mineral density in men with low T and ambulatory dysfunction after incomplete or complete SCI, along with muscle fundtion and walking recovery in men with T low and ambulatory dysfunction ater incomplete SCI.

NCT ID: NCT04387305 Not yet recruiting - Hemorrhage Clinical Trials

Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study

TIC-TOC
Start date: October 1, 2024
Phase: Phase 3
Study type: Interventional

Trauma is the leading cause of death and disability in children in the United States. The objective of this study is to evaluate the benefits and harms of tranexamic acid (TXA; a drug that stops bleeding) in severely injured children with hemorrhagic brain and/or torso injuries. Using thromboelastography, we will measure baseline fibrinolysis to assess for treatment effects of TXA at different levels of fibrinolysis.

NCT ID: NCT03805646 Completed - Wounds and Injury Clinical Trials

Mobile Phone-administered Triage Tool to Followup on Discharged Trauma Patients

Start date: August 5, 2019
Phase: N/A
Study type: Interventional

After being admitted to and then discharged from a hospital in Cameroon for having experienced an injury, there is no established way for the health system to check in on how the discharged person is doing. The investigators have developed a set of questions with the hope that asking these questions--over the phone--to those who have been discharged from the hospital will allow them to determine which post-discharge patients would benefit from further care. The investigators believe that asking these questions over the phone is a good way of determining which post-discharge trauma patients would benefit from further care.

NCT ID: NCT03764930 Completed - Retinoblastoma Clinical Trials

Attention to Retinoblastoma Diagnosed in the Trauma Setting

Start date: January 1, 2013
Phase:
Study type: Observational

To study the clinical characteristics and treatment outcomes of patients who experienced inadvertent trauma before diagnosis of retinoblastoma.

NCT ID: NCT03400345 Recruiting - Hand Injuries Clinical Trials

Human Upper Extremity Allotransplantation: F/U Protocol

Start date: July 25, 2017
Phase:
Study type: Observational

Upper extremity allotransplantation is a new procedure which is becoming more common in the United States. Ongoing data collection for research purposes is vital to the long-term assessment as to the safety of the procedure and accompanying immunosuppression protocol, as well as quantifying patient outcomes and changes in quality of life. For these reasons, The Johns Hopkins Hand/Arm Transplantation Team is interested in enrolling transplanted patients in a follow-up protocol to continue collecting informative data to further the field of vascularized composite allotransplantation.