Wound Healing Clinical Trial
Official title:
Clinical Efficacy of Chlorhexidine-based Mouthrinse Formulations in Patients Undergoing Flap Surgery: a Triple Blind, Parallel-arm, Randomized Controlled Trial
Backround: No data on the adjunctive effects of hyaluronic acid (HA) in a post-surgery,
chlorhexidine (CHX) - based plaque control regimen are available. Also, contrasting evidence
is available regarding the efficacy of CHX-based formulations containing anti-discoloration
system (ADS). The aim of the present study was to evaluate the post-surgery gingival healing
as well as plaque, gingival inflammation, and staining levels following the use of a 0.2%
chlorhexidine (CHX) solution with or without anti-discoloration system (ADS) and 0.2%
hyaluronic acid (HA).
Methods: Patients undergoing flap surgery at sites with an intact or reduced but healthy
periodontium participated in a parallel-arm RCT. After surgery, patients used the assigned
mouthrinse (CHX+HA+ADS or CHX) for 21 days. At day 7 and 21, the Gingival Healing Index (GHI)
was used to assess the quality of flap closure at the interdental papilla. Plaque index
(PlI), Gingival Index (GI), Angulated bleeding score (AngBS), tooth and tongue staining were
also assessed.
n/a
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