Modulation of Brain Oscillations Underlying Working Memory

Working Memory Clinical Trial

Official title: State-dependent Modulation of Interactions of Theta and Gamma Rhythms in Working Memory

Status Not yet recruiting

Clinical Trial Summary

This study will use novel transcranial alternating current stimulation (tACS) protocols and electroencephalography (EEG) to modulate and measure brain oscillations that underlie working memory. tACS is a noninvasive method used to modulate the timing and patterns of brain rhythms via weak electric currents passed through electrodes on the scalp.

Clinical Trial Description

In this study, healthy adult individuals will perform a spatial working memory task as investigators record scalp EEG before and immediately after undergoing transcranial alternating current stimulation (tACS). Each participant will complete four tACS sessions in randomized order: 1) theta-nested gamma tACS applied during active task periods, 2) theta-nested gamma tACS applied during passive (rest) periods, 3) gamma stimulation applied in phase with ongoing theta oscillations, and 4) placebo tACS. The different stimulation protocols will take place on different days. Therefore, participants will be expected to attend 4 in-person study visits at the Martinos Center for Biomedical Imaging in Charlestown, Massachusetts. ;

Related Conditions & MeSH terms

• Working Memory

• NCT number: NCT05923606
• Study type: Interventional
• Source: Massachusetts General Hospital
• Contact: Alexandra O'Neill, B.S.
• Phone: (617) 726-8753
• Email: agoneill@mgh.harvard.edu
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 1, 2024
• Completion date: August 31, 2026