Traveling-wave Transcranial Electric Stimulation

Working Memory Clinical Trial

— TravelingTES  

Official title:

Precision Transcranial Electric Stimulation for the Therapy of Cognitive Impairment

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05399381
• Other study ID #: STUDY00002876
• Secondary ID: 30064
• Status: Recruiting
• Phase: N/A
• Start date: September 5, 2022
• Est. completion date: December 30, 2025

Study information

• Verified date: January 2024
• Source: University of Minnesota
• Contact: Ivan Alekseichuk, PhD
• Phone: 612-624-1118
• Email: ialeksei[@]umn.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will assess the impact of traveling wave transcranial alternating current stimulation (tACS) on working memory performance in adults.

Description:

Transcranial alternating current stimulation (tACS) can non-invasively alter neuroelectric activity in the brain by applying weak time-varying electric currents via the scalp. Complex patterns of electric brain activity can take the form of traveling waves - spatially coherent brain rhythms that gradually propagate through the neocortex. Traveling waves are crucial for the temporal coordination of informational flow in the brain. Using the novel traveling-wave transcranial alternating current stimulation (tACS) approach, the investigators will explore the effects of frontal-to-parietal and parietal-to-frontal traveling waves on working memory performance and brain electrophysiology in adults.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 24
• Est. completion date: December 30, 2025
• Est. primary completion date: December 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

1. Age between 18 and 45 years old.

2. Confident level of English language.

Exclusion Criteria:

1. History or evidence of chronic neurological or mental disorder.

2. Metal or electric implant in the head, neck, or chest area.

3. History of head injuries with loss of consciousness.

4. Any acute or chronic medical condition that requires ongoing pharmacological treatment.

5. Pregnancy or breast-feeding.

6. Alcohol or drug addiction.

Related Conditions & MeSH terms

• Working Memory

Intervention

Device:
• Transcranial alternating current stimulation (tACS)
Non-invasive, multi-electrode transcranial alternating current stimulation (tACS) over frontal and parietal brain areas.

Locations

Country	Name	City	State
United States	University of Minnesota	Minneapolis	Minnesota

Sponsors (2)

Lead Sponsor	Collaborator
University of Minnesota	Brain & Behavior Research Foundation

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in working memory performance	Changes in working memory performance (% of correct responses) as measured with the standardized N-back working memory task during active stimulation relative to pre-stimulation performance.	Immediate effect during stimulation
Secondary	Changes in reaction time	Changes in reaction time (milliseconds) as measured using the standardized N-back working memory task during active stimulation relative to pre-stimulation performance.	Immediate effect during stimulation
Secondary	Changes in electroencephalographic (EEG) connectivity	Changes in electroencephalographic (EEG) connectivity in theta band (in normalized units) after transcranial electric stimulation relative to pre-stimulation periods.	Five minutes post-stimulation