Women's Health Clinical Trial
Official title:
Investigating the Effects of Probiotics on Synaptic Plasticity in the Follicular and Luteal Phases of the Menstrual Cycle
Modulation of our gut microbiota through probiotics, can improve our emotional state, decrease pain sensitivity, improve cognitive processes, increase neurotransmitter levels and alter functional connectivity. In addition, probiotics regulate estrogen levels. Estrogen levels have been recognized to influence the gut microbiota, impact neural activity, memory, and cognition. This study aims 1) to determine whether probiotics can increase the propensity for synaptic plasticity in females and 2) to determine if there are differences in the propensity for plasticity depending on the phase of the menstrual cycle.
Status | Not yet recruiting |
Enrollment | 40 |
Est. completion date | May 2025 |
Est. primary completion date | May 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - right handed, females between 18-35 years old with a regular menstrual cycle (approximately 26-30 days) Exclusion Criteria: - contradictions to TMS - contradictions to probiotic - Females who use hormone altering devices (i.e. oral contraceptives) |
Country | Name | City | State |
---|---|---|---|
Canada | McMaster Unviersity | Hamilton | Ontario |
Lead Sponsor | Collaborator |
---|---|
McMaster University |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change Motor Evoked Potentials (MEPs) | Change in MEPs using TMS | Immediately before intervention, immediately following 4 week intervention | |
Secondary | Short Interval intracortical inhibition (SICI) | Changes in SICI Using TMS | Immediately before intervention, immediately following 4 week intervention |
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