Resistance Training and Sex Hormone Concentrations During the Menstrual Cycle

Women's Health Clinical Trial

Official title:

Acute Effects of Resistance Training on Sex Hormone Concentrations on Different Phases of the Menstrual Cycle

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04163380
• Other study ID #: 111B
• Status: Recruiting
• Phase: N/A
• Start date: November 1, 2019
• Est. completion date: December 2021

Study information

• Verified date: May 2019
• Source: Southern Illinois University Edwardsville
• Contact: Maria Fernandez del Valle, PhD
• Phone: 6186505905
• Email: marfern[@]siue.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Although there are numerous studies showing effects of aerobic training on sex hormone concentrations, research analyzing the fluctuation of sex hormones in response to resistance training (RT) is lacking. The objective of this project is to analyze estradiol (E2) and progesterone (P4) responses to an acute resistance training session throughout different phases of the menstrual cycle. This proposed research has strong implications for exercise prescription and for women in general, but more importantly will allow exercise physiologists, coaches, personal trainers, or nutritionists optimize exercise programming around women's menstrual cycle.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 25
• Est. completion date: December 2021
• Est. primary completion date: December 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Eumenorrheic females

• Age 18-45 years old

• BMI of 18.5-34.99 kg/m2

Exclusion Criteria:

• Practice exercise more than 2 days/week in the last 3 months.

• Cardiovascular, metabolic, pulmonary or muscular-skeletal condition

• Taking medications that affect metabolism (e.g. oral contraceptives)

• Irregular menstrual cycles

Related Conditions & MeSH terms

• Women's Health

Intervention

Behavioral:
• Resistance Training
Participants will exercise at the mid-point of each menstrual cycle phase (EFP- day 4, LFP- day 11, ELP- day 18 and LLP- day 25 for a 28 day menstrual cycle). Training will consist of a warm up. Intensity will be set at 70% of 1RM, and the circuit training will include 7 strength exercises: leg press, rows, back squat, weighted crunches, deadlifts, bench press, and weighted squat jumps. The participant will perform 3 sets f 10 repetitions with 30 seconds of rest

Locations

Country	Name	City	State
United States	Southern Illinois University Edwardsville	Edwardsville	Illinois

Sponsors (1)

Lead Sponsor	Collaborator
Southern Illinois University Edwardsville

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in estrogen concentrations	Estrogen concentrations will be obtained from blood samples assessed using through ELISA kits	through study completion, an average of 5 weeks
Primary	Change in progesterone concentrations	Progesterone concentrations will be obtained from blood samples assessed using through ELISA kits	through study completion, an average of 5 weeks
Secondary	Lean body mass (kg)	Lean body mass (kg) will be assessed through Dual-energy X-ray Absorptiometry	At baseline: 1 assessment point
Secondary	Fat mass (kg)	Fat mass (kg) will be assessed through Dual-energy X-ray Absorptiometry	At baseline: 1 assessment point
Secondary	Relative body fat (%)	Relative body fat (%) will be assessed through Dual-energy X-ray Absorptiometry	At baseline: 1 assessment point
Secondary	Skeletal muscle mass (kg)	Skeletal muscle mass (kg) will be estimated using Dual-energy X-ray Absorptiometry values	At baseline: 1 assessment point
Secondary	Cardiorespiratory Fitness	Cardiorespiratory Fitness will be assessed with a cardiopulmonary exercise test using the Bruce protocol	At baseline: 1 assessment point
Secondary	Strength in Bench Press	Maximal strength bench press will be assessed using one repetition maximum test	At baseline: 1 assessment point
Secondary	Strength in Leg Press	Maximal strength in leg press will be assessed using one repetition maximum test	At baseline: 1 assessment point
Secondary	Changes in diet	Diet will be assessed using the a 24h dietary recall	through study completion, an average of 5 weeks