Urinary Continence of Female POPRC and OIN

Urinary Incontinence Clinical Trial

Official title: Urinary Continence of Female Pelvic Organ-preserving Radical Cystectomy and Orthotopic Ileal Neobladder: A Randomized Controlled Study

Status Not yet recruiting

Clinical Trial Summary

To compare the urinary continence rate and long-term oncological outcomes of pelvic-organ preserving radical cystectomy (POPRC) with orthotopic ileal neobladder (OIN) versus standard radical cystectomy(SRC) with OIN.

Clinical Trial Description

Radical cystectomy is the gold standard for muscle-invasive bladder. Orthotopic ileal neobladder, as one of the urinary diversion methods, is preferred whenever possible to achieve a better postoperative quality of life.

For standard radical cystectomy (SRC) in females, the uterus, fallopian tubes, ovaries, anterior vaginal wall, and regional lymph nodes undergo en bloc resection with the bladder and urethra . With regard to the wide range of resection, continence disorder and sexual dysfunction are very common after surgery. Pelvic-organ sparing radical cystectomy involves the preservation of the female vagina, uterus, neurovascular bundles, and any enhancement of the aforementioned techniques . Previous studies demonstrated that POPRC might not affect long-term survival and instead improve continence outcomes. However, most of the available studies are retrospective with limited cases in a single center. The current study primarily aims to urinary continence rate and long-term oncological outcomes of POPRC+OIN versus SRC+OIN in a prospective randomized controlled trial. ;

Related Conditions & MeSH terms

• Sexual Dysfunction, Physiological
• Treatment Outcome
• Urinary Bladder Neoplasms
• Urinary Incontinence
• Woman

• NCT number: NCT05325216
• Study type: Interventional
• Source: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
• Contact: Wenlong Zhong, MD
• Phone: 86-18510904167
• Email: zhongwlong3@mail.sysu.edu.cn
• Status: Not yet recruiting
• Phase: N/A
• Start date: April 2022
• Completion date: April 1, 2028