White Spot Lesions Clinical Trial
Official title:
Compare the Efficacy of the Remineralization Agents on the White Enamel Lesions
The purpose of this study is to determine whether Fluoride varnish + calcium (Clinpro White Varnish) and polipeptide solution (Curodont Repair) are effective in the treatment of remineralization therapy. The investigators will diagnose their alone or in combination effects on white spot lesions. Aesthetics (tooth-colored), remineralization, microbiological effects will be evaluated separately. Spectrophotometer (Vita Easy Shade) , Quantitative Light Fluorescence (QLF), Diagnodent(Cavo Diagnodent) and culture methods in microbiology laboratories are used for aesthetic, remineralization and microbiological assessments. The measurements will be made baseline, 6 weeks, 3 months and 6 months later after the applications and recorded.
The aim of this study is that evaluate the remineralizing and antibacterial effects of the
different remineralization agents. Initiative caries lesions named as white spot lesions and
these lesions are localized at enamel. Demineralization is occured but cavitations aren't
seen at this stage. It is important to control at this stage with remineralization agents
because of the minimally invasive approach.
Fluoride varnish or polipeptide containing agents alone or combination using effects on
remineralization, esthetic and bacterial counts will be evaluated with Quantitive Light
Fluorescence , Diagnodent (Cavo-Diagnodent), Spectrophotometer (Vita Easy Shade) devices and
microbiological assessment at laboratory.
The investigators will choose and include in our study that who come to the Ege University
Faculty of Dentistry pediatric department, between 10-18 years olds, healthy and have one or
more white spot lesions on her/his permanent teeth.
32 volunteer who have inclusion criteria will be put into pratice. 32 volunteer divided into
4 groups for different applications. We will tell each volunteer that they must brush their
teeth twice a day with fluoride dentifrice ( the investigators will give them 1400 ppm
fluoride containing fluoride dentifrice)
1. Group: Control group ( The investigators won't do any application , the oral hygiene
konwledge will be given only.)
2. Group: Fluoride + Calcium (TCP) (The investigators will do fluoride+ calcium varnish(
Clinpro white varnish) application on white spot lesions)
3. Group: Polipeptide solution (The investigators will do polipeptide ( Curodont repair)
solution application on white spot lesions)
4. Group: [Fluoride + calcium varnish] + polipeptide solution combination ( The
investigators will do polipeptide ( Curodont repair) solution and fluoride + calcium
varnish (Clinpro white varnish) application on white spot lesions) First day,the
investigators will collect stimulated saliva from each volunteer before any
application. Saliva samples will transport to the microbiology laboratory. After any
application 6 weeks, 3 months and 6 months later we will collect stimulated saliva
again for microbiological assessment.
Nyvad Caries Diagnostic Criteria , ICDAS indexes will be used to make the follow-up of
lesions at baseline and 6 months after the application. Plaque index (Silness & Löe , 1964)
and bleeding index (Ainamo&Bay ,1976) will be used to assess oral hygiene every visit.
The investigators will use QLF,Diagnodent devices will be used at beginning for evaluate the
demineralization level and after applications 6 weeks, 3 months and 6 months later used for
evaluate the remineralization level. In addition for determine about esthetic results the
investigators will use spectrophotometer (Vita Easy Shade) device at beginning, 6 weeks, 3
months and 6 months later.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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