White Spot Lesion Clinical Trial
Official title:
İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
Verified date | December 2023 |
Source | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
With our study, we aimed to determine whether there is a correlation between zonulin, which plays a crucial role in intestinal barrier function and is implicated in the etiopathogenesis of many chronic and autoimmune diseases, and scattered white spots lesions associated with lymphatic stasis and inflammation in the duodenum.
Status | Completed |
Enrollment | 93 |
Est. completion date | December 1, 2023 |
Est. primary completion date | December 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria: - Patients with scattered white patchy lesions in the duodenum on endoscopy and control group patients with normal duodenum on endoscopy. Exclusion Criteria: - active gastroenteritis - acute kidney failure - chronic kidney failure - type-1 diabetes - inflammatory bowel disease - duodenal ulcer, - duodenal tumor - autoimmune diseases |
Country | Name | City | State |
---|---|---|---|
Turkey | Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital | Ankara |
Lead Sponsor | Collaborator |
---|---|
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital |
Turkey,
Biyikoglu I, Babali A, Cakal B, Koklu S, Filik L, Astarci MH, Ustun H, Ustundag Y, Akbal E. Do scattered white spots in the duodenum mark a specific gastrointestinal pathology? J Dig Dis. 2009 Nov;10(4):300-4. doi: 10.1111/j.1751-2980.2009.00399.x. — View Citation
Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep;2(9):416-22. doi: 10.1038/ncpgasthep0259. — View Citation
Tas A, Koklu S, Beyazit Y, Akbal E, Kocak E, Celik H, Biyikoglu I. The endoscopic course of scattered white spots in the descending duodenum: a prospective study. Gastroenterol Hepatol. 2012 Feb;35(2):57-64. doi: 10.1016/j.gastrohep.2011.11.010. Epub 2012 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | zonulin levels | Patients with scattered white spots in the duodenum had blood drawn for zonulin level immediately after the procedure. | immediately after the procedure | |
Secondary | Duodenal and gastric pathologic conditions | Biopsies from the duodenum and gastric antrum and corpus were taken during the endoscopy from patients with scattered white spots in the duodenum. | During the endoscopy |
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